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首页> 外文期刊>Biochemical Pharmacology >Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats
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Chronic hydrogen-rich saline treatment attenuates vascular dysfunction in spontaneous hypertensive rats

机译：慢性富氢盐水治疗可减轻自发性高血压大鼠的血管功能障碍

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摘要

In hypertensive patients, increased oxidative stress is thought to be one important cause of vascular dysfunction. Recently, it has been suggested that hydrogen exerts a therapeutic antioxidant activity by selectively reducing hydroxyl radical and peroxynitrite, the most cytotoxic chemicals of reactive oxygen species (ROS). Herein, we investigated the protective effect of chronic treatment with hydrogen-rich saline (HRS) against vascular dysfunction in SHR and the underlying mechanism. The 8-week-old spontaneously hypertensive rats (SHR) and age-matched Wistar-Kyoto rats (WKY) were randomized into HRS-treated (6 ml/kg/day for 3 months, i.p.) and vehicle treated group. Treatment with HRS ameliorated vascular dysfunction including aortic hypertrophy and endothelial function in SHR. Treatment with HRS had no significant effect on blood pressure, but it significantly improved baroreflex function in SHR. Treatment with HRS abated oxidative stress, restored antioxidant enzymes including superoxide dismutase, glutathione peroxidase, and catalase, and suppressed NADPH oxidase. Furthermore, treatment with HRS depressed pro-inflammatory cytokines expression including IL-6 and IL-1β and suppressed NF-κB activation, restored mitochondrial function including ATP formation and membrane integrity. In addition, although treatment with HRS had no significant effect on nitric oxide amount in circulating or aorta, it suppressed endothelial nitric oxide synthase expression and upregulated dimethylarginine dimethylaminohydrolase 2 expression in SHR. In conclusion, treatment with HRS alleviates vascular dysfunction through abating oxidative stress, restoring baroreflex function, suppressing inflammation, preserving mitochondrial function, and enhancing nitric oxide bioavailability.
机译：在高血压患者中，氧化应激的增加被认为是血管功能障碍的重要原因之一。近来，已经提出氢通过选择性还原羟基自由基和过氧亚硝酸盐而发挥治疗抗氧化活性，过氧亚硝酸盐是活性氧（ROS）的最具细胞毒性的化学物质。在这里，我们调查了慢性富氢盐水（HRS）对SHR血管功能障碍的保护作用及其潜在机制。将8周大的自发性高血压大鼠（SHR）和年龄匹配的Wistar-Kyoto大鼠（WKY）随机分为HRS治疗组（6 ml / kg /天，共3个月，腹腔注射）和溶媒治疗组。 HRS改善了SHR中包括主动脉肥大和内皮功能在内的血管功能障碍。 HRS治疗对血压无明显影响，但可显着改善SHR的压力反射功能。用HRS进行治疗可减轻氧化应激，恢复包括超氧化物歧化酶，谷胱甘肽过氧化物酶和过氧化氢酶在内的抗氧化酶，并抑制NADPH氧化酶。此外，HRS治疗抑制了包括IL-6和IL-1β在内的促炎性细胞因子的表达，并抑制了NF-κB的活化，恢复了包括ATP形成和膜完整性在内的线粒体功能。另外，尽管用HRS处理对循环或主动脉中一氧化氮的量没有显着影响，但是它抑制了SHR中内皮型一氧化氮合酶的表达并上调了二甲基精氨酸二甲基氨基水解酶2的表达。总之，HRS的治疗可通过减轻氧化应激，恢复压力反射功能，抑制炎症，保持线粒体功能以及增强一氧化氮的生物利用度来缓解血管功能障碍。

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