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首页> 外文期刊>Ear, nose and throat journal >Distortion-product otoacoustic emissions testing in neonates treated with an aminoglycoside in a neonatal intensive care unit
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Distortion-product otoacoustic emissions testing in neonates treated with an aminoglycoside in a neonatal intensive care unit

机译：新生儿重症监护病房中用氨基糖苷治疗的新生儿的畸变产物耳声发射测试

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摘要

We evaluated the ototoxic effect of aminoglycosides on the outer hair cells of newborns in a neonatal intensive care unit (NICU) by means of distortion-product otoacoustic emissions (DPOAE) testing. Our study population was made up of 164 newborns who were divided into three groups: group A consisted of 105 infants who were given aminoglycoside therapy (either gentamicin or amikacin, or a combination of the two) as treatment for suspected or proven bacterial infection and septic states; group B included 30 newborns who were not given an antibiotic or who were given an antibiotic other than an aminoglycoside; group C, a control group, was made up of 29 healthy neonates who were hospitalized in the well-baby nursery. All the neonates underwent DPOAE testing in both ears (the f(2) primary tone was presented at 2.0, 2.5, 3.2, and 4.0 kHz). We found that 41 patients in group A (39.0%) and 13 in group B (43.3%) failed the DPOAE test in one or both ears; the difference between these two groups was not statistically significant (p = 0.673). In group C, the DPOAE fail rate was 13.8% (4 newborns). In group A, there was no statistically significant association between the pass/fail rate and the specific aminoglycoside that was administered, or in the duration of antibiotic treatment, the number of doses, and the size of the mean daily dose and the mean total dose. In clinical practice, DPOAE testing is a sensitive method of evaluating the integrity of the outer hair cells in the basal turn of the cochlea after exposure to ototoxic drugs such as aminoglycosides. However, our study did not demonstrate that the aminoglycosides had any ototoxic effect on the hearing of neonates in the NICU.
机译：我们通过畸变产物耳声发射（DPOAE）测试评估了氨基糖苷对新生儿重症监护病房（NICU）新生儿外毛细胞的耳毒性作用。我们的研究人群由164个新生儿组成，分为三组：A组由105例婴儿组成，他们接受了氨基糖苷类药物治疗（庆大霉素或丁胺卡那霉素或两者的组合），以治疗可疑或确诊的细菌感染和败血症。状态; B组包括30名未给予抗生素或除氨基糖苷以外的其他抗生素的新生儿; C组为对照组，由29名健康婴儿组成，他们在婴儿托儿所住院。所有新生儿都在两只耳朵中接受了DPOAE测试（f（2）主音出现在2.0、2.5、3.2和4.0 kHz）。我们发现，A组中的41名患者（39.0％）和B组中的13名患者（43.3％）在一只或两只耳朵中均未通过DPOAE测试。两组之间的差异无统计学意义（p = 0.673）。在C组中，DPOAE失败率为13.8％（4例新生儿）。在A组中，通过/未通过率与所施用的特定氨基糖苷之间，或在抗生素治疗期间，剂量数，平均日剂量和平均总剂量的大小之间，在统计学上没有显着相关性。 。在临床实践中，DPOAE测试是评估暴露于耳毒性药物（如氨基糖苷类）后耳蜗基底转弯中外毛细胞完整性的灵敏方法。但是，我们的研究并未证明氨基糖苷类药物对重症监护病房新生儿的听力有任何耳毒性作用。

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