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首页> 外文期刊>Early human development >Risk factors for intubation-surfactant-extubation (INSURE) failure and multiple INSURE strategy in preterm infants.
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Risk factors for intubation-surfactant-extubation (INSURE) failure and multiple INSURE strategy in preterm infants.

机译:早产儿插管-表面活性剂-拔管(INSURE)失败和多种INSURE策略的危险因素。

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摘要

The INSURE method, which consists of an intubation-surfactant-extubation sequence, is effective in reducing the need for mechanical ventilation (MV), the duration of respiratory support, and the need for surfactant replacement in preterm infants with respiratory distress syndrome. Although beneficial, the INSURE method fails to avoid MV in selected patients. We demonstrated that body weight <750 g, pO(2)/FiO(2) <218, and a/ApO(2) <0.44 at the first blood gas analysis are independent risk factors for INSURE failure in infants with gestational age <30 weeks. Moreover, we demonstrated that the INSURE treatment can be safely repeated with the aim to avoid MV, since the respiratory outcome did not differ between infants treated with single or multiple INSURE procedures.
机译:INSURE方法由插管-表面活性剂-拔管程序组成,可有效减少呼吸窘迫综合征早产儿的机械通气(MV)需求,呼吸支持持续时间和表面活性剂替代需求。尽管有益,但INSURE方法无法避免某些患者出现MV。我们证明,在第一次血气分析时,体重<750 g,pO(2)/ FiO(2)<218和a / ApO(2)<0.44是造成胎龄<30岁的婴儿INSURE失败的独立危险因素周。此外,我们证明了可以安全地重复进行INSURE治疗,从而避免了MV,因为单次或多次INSURE手术治疗的婴儿的呼吸结局无差异。

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