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Neonatal creatinemia trends as biomarker of subsequent cognitive outcome in extremely low birth weight neonates

机译:新生儿肌酐血症是极低出生体重新生儿随后认知结局的生物标志物

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Background and aims: Serum creatinine is traditionally used as a marker of renal function in neonates and relates to gestational age and disease severity in extremely low birth weight (ELBW) infants. Creatinine is commonly used as a biomarker for early morbidity, but we aim to compare postnatal creatinemia trends as a biomarker for subsequent cognitive outcome. We hypothesize that impaired microcirculation not only in the kidney, but also in general (i.e. brain development) can explain this possible link.
机译:背景与目的:血清肌酐传统上被用作新生儿肾功能的标志物,并且与极低出生体重(ELBW)婴儿的胎龄和疾病严重程度有关。肌酐通常用作早期发病的生物标志物,但我们的目标是比较产后肌酐水平的趋势,作为后续认知结果的生物标志物。我们假设不仅在肾脏中微循环受损,而且在一般情况下(即大脑发育)受损也可以解释这种可能的联系。

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