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Pregnancy and other pituitary disorders (including GH deficiency)

机译：怀孕和其他垂体疾病（包括生长激素缺乏症）

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摘要

The pituitary gland is one of the most affected organs with altered anatomy and physiology during pregnancy. Acromegaly is the second most common pituitary adenoma seen in relation to gestation after prolactinomas. Acromegaly should be treated before conception to prevent potential tumor growth in patients who desire fertility. Medical therapy can be ceased safely after confirmation of pregnancy in acromegalic patients, but octreotide may be used in selected cases with compressive signs. Other hormonal and non-functional tumors are rarer and have been presented as case reports. Sheehan's syndrome, which is one of the most common causes of hypopituitarism in developing countries, and lymphocytic hypophysitis are known to be associated with pregnancy. They usually result in hypopituitarism, sometimes with delays in diagnosis and difficulties in differential diagnosis. Pregnancy is not common among patients with hypopituitarism or pituitary adenomas due to altered gonadotroph functions. Ovulation induction is essential for fertility achievement, but the replacement of other deficient pituitary hormones, including GH, seems to play an important role in the preparation of the uterus for implantation of the embryo.
机译：垂体是怀孕期间受影响最严重的器官之一，其解剖结构和生理发生变化。肢端肥大症是继泌乳素瘤之后第二大最常见的垂体腺瘤。怀孕前应治疗肢端肥大症，以防止需要生育的患者潜在的肿瘤生长。肢端肥大症患者确认怀孕后可以安全地停止药物治疗，但在某些有压迫症状的病例中可以使用奥曲肽。其他激素和非功能性肿瘤较为罕见，并已作为病例报告提出。希恩氏综合症是发展中国家垂体机能减退的最常见原因之一，而淋巴细胞性垂体炎与妊娠有关。它们通常会导致垂体功能低下，有时会延误诊断并难以进行鉴别诊断。由于性腺功能改变，垂体功能低下或垂体腺瘤患者不常见妊娠。排卵诱导对于实现生育能力至关重要，但是，替代其他缺乏的垂体激素（包括GH）在准备子宫植入胚胎的过程中似乎起着重要作用。

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