• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Islets >Resveratrol fails to improve marginal mass engraftment of transplanted islets of Langerhans in mice
【24h】

Resveratrol fails to improve marginal mass engraftment of transplanted islets of Langerhans in mice

机译：白藜芦醇不能改善小鼠朗格汉斯胰岛的边缘团块植入

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One limitation of current islet transplantation protocols is the loss of up to 70% of the transplanted islet mass. Inflammatory events play a major role in islet loss including the cytokines TNFα and IL-1. Resveratrol, a compound with anti-inflammatory and anti-oxidant properties, has the potential to mitigate islet loss. Using a syngeneic marginal after mouse islet transplantation model we tested the ability of resveratrol to enhance islet engraftment. We failed to show a difference in diabetes reversal between mice treated with vehicle and those treated with either 10 mg/kg (47.1% for resveratrol vs. 35.3% for control) or 50 mg/kg (20% for resveratrol vs. 22.2% for control) of resveratrol daily for three weeks. In addition, at one month there was no difference in glucose tolerance or graft survival (10 mg/kg: 552.6 ng/ml resveratrol group vs. 576.6 ng/ml control group; 50 mg/kg: 463 ng/ml resveratrol group vs. 444.1 ng/ml control group). In summary, over a wide range of doses, resveratrol did not exert a benefit on mouse islet engraftment. Further studies should be conducted with human islets before deeming resveratrol ineffective in islet engraftment and survival.
机译：当前胰岛移植方案的局限性之一是损失了高达70％的移植胰岛。炎症事件在胰岛丢失中起主要作用，包括细胞因子TNFα和IL-1。白藜芦醇是具有抗炎和抗氧化特性的化合物，具有减轻胰岛丢失的潜力。使用小鼠胰岛移植后的同源边缘，我们测试了白藜芦醇增强胰岛移植的能力。我们没有显示用媒介物治疗的小鼠和用10 mg / kg（白藜芦醇为47.1％，而对照为35.3％）或50 mg / kg（白藜芦醇为20％，而白藜芦醇为22.2％）的小鼠在糖尿病逆转方面没有差异。对照）白藜芦醇，持续三周。此外，在一个月的时间里，葡萄糖耐量或移植物存活率没有差异（10 mg / kg：552.6 ng / ml白藜芦醇组与576.6 ng / ml对照组; 50 mg / kg：463 ng / ml白藜芦醇组。对照组为444.1 ng / ml）。总之，在很宽的剂量范围内，白藜芦醇对小鼠胰岛移植没有益处。在认为白藜芦醇对胰岛的植入和存活无效之前，应对人的胰岛进行进一步的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号