...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Glia >APOE Genotype-Dependent Modulation of Astrocyte Chemokine CCL3 Production
【24h】

APOE Genotype-Dependent Modulation of Astrocyte Chemokine CCL3 Production

机译：APOE基因型依赖的星形胶质细胞趋化因子CCL3生产的调节。

获取原文
获取原文并翻译 | 示例
   

获取外文期刊封面封底 >>

       
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Apolipoprotein E (apoE) is well known as a regulator of cholesterol homeostasis, and is increasingly recognized to play a prominent role in the modulation of innate immune response, including cell-to-cell communication and migration. Alzheimer's disease (AD) is a slowly progressive neurodegenerative disorder characterized by neuroinflammation that appears to be an important component of the pathophysiology of the disease. Astrocytes are the majority cell type in brain, exerting significant influence over a range of central nervous system activities, including microglial-mediated neuroinflammatory responses. As the resident innate immune effector cells of the brain, microglia respond to soluble chemical signals released from tissue during injury and disease by mobilizing to lesion sites, clearing toxic molecules, and releasing chemical signals of their own. While microglial-mediated neuroinflammation in the AD brain remains an area of intense investigation, the mechanisms underlying reinforcement and regulation of these aberrant microglial responses by astrocytes are largely unstudied. Moreover, although inheritance of APOE 4 represents the greatest genetic risk factor for sporadic AD, the mechanism by which apoE isoforms differentially influence AD pathophysiology is unknown. Here we show that APOE 4 genotype specifically modulates astrocyte secretion of potent microglial chemotactic agents, including CCL3, thus providing evidence that APOE modulation of central nervous system (CNS) innate immune response is mediated through astrocytes. GLIA 2015;63:51-65
机译：载脂蛋白E（apoE）是胆固醇稳态的调节剂，众所周知，它在调节先天免疫应答（包括细胞间通讯和迁移）中起着重要作用。阿尔茨海默氏病（AD）是一种以神经炎症为特征的缓慢进行性神经退行性疾病，似乎是该疾病病理生理学的重要组成部分。星形胶质细胞是大脑中的主要细胞类型，在一系列中枢神经系统活动（包括小胶质细胞介导的神经炎症反应）中发挥着重要作用。作为大脑的固有先天免疫效应细胞，小胶质细胞通过动员到病变部位，清除有毒分子并释放自身的化学信号，来响应在损伤和疾病期间从组织释放的可溶性化学信号。尽管AD脑中小胶质细胞介导的神经炎症仍是一个研究热点，但星形胶质细胞对这些异常小胶质细胞应答的增强和调节的机制尚待研究。此外，尽管APOE 4的遗传代表了散发性AD的最大遗传风险因素，但apoE亚型差异影响AD病理生理的机制尚不清楚。在这里，我们显示APOE 4基因型特异性调节有效的小胶质细胞趋化剂（包括CCL3）的星形胶质细胞分泌，从而提供证据表明星形胶质细胞介导APOE调节中枢神经系统（CNS）固有免疫反应。 GLIA 2015; 63：51-65

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号