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首页> 外文期刊>Glia >Interleukin 15 expression in the CNS: Blockade of its activity prevents glial activation after an inflammatory injury
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Interleukin 15 expression in the CNS: Blockade of its activity prevents glial activation after an inflammatory injury

机译：白细胞介素15在中枢神经系统中的表达：阻断其活性可防止炎症性损伤后神经胶质的活化

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摘要

Although reactive glia formation after neuronal degeneration or traumatic damage is one of the hallmarks of central nervous system (CNS) injury, we have little information on the signals that direct activation of resting glia. IL-15, a pro-inflammatory cytokine involved in regulating the response of T and B cells, may be also key for the regulation of early inflammatory events in the nervous system. IL-15 was expressed in the CNS, most abundantly in cerebellum and hippocampus, mainly in astrocytes and in some projection neurons. Using a rodent model of acute inflammatory injury [lipopolysaccharide (LPS) injection], we found enhanced expression of IL-15 in both reactive astroglia and microglia, soon after CNS injury. Blockade of IL-15 activity with an antibody to the cytokine, reversed activation of both glial types, suggesting that IL-15 has a major role in the generation of gliotic tissue and in the regulation of neuroimmune responses. Because IL-15 appears to modulate the inflammatory environment acutely generated after CNS injury, regulating IL-15 expression seems a clear antiinflammatory therapy to improve the outcome of neurodegenerative diseases and CNS trauma. (C) 2008 Wiley-Liss, Inc.
机译：尽管神经元变性或创伤性损伤后反应性胶质细胞形成是中枢神经系统（CNS）损伤的标志之一，但我们对指导静息胶质细胞激活的信号知之甚少。 IL-15，一种参与调节T细胞和B细胞反应的促炎性细胞因子，也可能是调节神经系统早期炎症事件的关键。 IL-15在中枢神经系统中表达最多，在小脑和海马中最丰富，主要在星形胶质细胞和某些投射神经元中表达。使用急性炎性损伤[脂多糖（LPS）注射]的啮齿动物模型，我们发现中枢神经系统损伤后不久，反应性星形胶质细胞和小胶质细胞中IL-15的表达增强。用针对细胞因子的抗体阻断IL-15的活性会逆转两种神经胶质类型的激活，这表明IL-15在神经胶质组织的生成和神经免疫应答的调节中起主要作用。因为IL-15似乎可以调节中枢神经系统损伤后急性产生的炎症环境，所以调节IL-15的表达似乎是改善神经退行性疾病和中枢神经系统损伤预后的明确抗炎治疗方法。 （C）2008 Wiley-Liss，Inc.

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