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首页> 外文期刊>Glia >Rehabilitative therapies differentially alter proliferation and survival of glial cell Populations in the perilesional zone of cortical infarcts
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Rehabilitative therapies differentially alter proliferation and survival of glial cell Populations in the perilesional zone of cortical infarcts

机译：康复治疗差异性地改变了皮层梗死病灶周围区域胶质细胞的增殖和存活

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摘要

Rehabilitative therapies after stroke are designed to improve remodeling of neuronal circuits and to promote functional recovery. Only very little is known about the underlying cellular mechanisms. In particular, the effects of rehabilitative training on glial cells, which play an important role in the pathophysiology of cerebral ischemia, are only poorly understood. Here, we examined the effects of rehabilitative therapies on proliferation and survival of distinct glial populations in the perilesional area of photochemically induced focal ischemic infarcts in the forelimb sensorimotor cortex in rats. Immediately after the infarct, one group of animals housed in standard cages received daily sessions of skilled reaching training of the impaired forelimb; a second group was transferred to an enriched environment, whereas a third control group remained in standard cages without further treatment. Functional recovery was assessed in a sensorimotor walking task. To label proliferating cells, bromodeoxyuridine (BrdU) was administered from day 2 until day 6 postinfarct. Proliferation and survival of astrocytes, microglia/macrophages, and immature and mature oligodendrocytes in the perilesional zone were immunocytochemically quantified at day 10 and 42. Using this approach, we demonstrate that enriched environment and reaching training both significantly improve functional recovery of the impaired forelimb. Furthermore, these therapies strongly reduce the proliferation of microglia/macrophages in the perilesional zone, and daily training of the impaired forelimb significantly increased the survival of newly generated astrocytes. Our data, therefore, demonstrate that rehabilitative therapies after cortical infarcts not only improve the functional recovery but also significantly influence the glial response in the perilesional zone. (C) 2008 Wiley-Liss, Inc.
机译：中风后的康复治疗旨在改善神经回路的重塑并促进功能恢复。关于潜在的细胞机制知之甚少。尤其是，康复训练对神经胶质细胞的作用，在脑缺血的病理生理中起着重要作用，人们对此知之甚少。在这里，我们检查了康复疗法对大鼠前肢感觉运动皮层光化学诱导的局灶性缺血性梗死病灶周围不同胶质细胞群增殖和存活的影响。梗塞后，立即将一组饲养在标准笼子中的动物接受每天的技能培训，以训练受损的前肢。第二组被转移到一个富裕的环境中，而第三组仍留在标准笼中，未经进一步处理。在感觉运动步行任务中评估功能恢复。为了标记增殖细胞，从梗塞后第2天到第6天给予溴脱氧尿苷（BrdU）。在第10天和第42天，通过免疫细胞化学方法定量分析了病灶周围区域中星形胶质细胞，小胶质细胞/巨噬细胞以及未成熟和成熟的少突胶质细胞的增殖和存活。使用这种方法，我们证明了丰富的环境和接受训练都可以显着改善受损前肢的功能恢复。此外，这些疗法极大地减少了小胶质细胞/巨噬细胞在病灶周围区域的增殖，每天对受损前肢进行训练显着提高了新产生的星形胶质细胞的存活率。因此，我们的数据表明，皮层梗死后的康复治疗不仅可以改善功能恢复，还可以显着影响病灶周围区域的神经胶质反应。 （C）2008 Wiley-Liss，Inc.

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