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Anti-Milllerian hormone and polycystic ovary syndrome

机译：抗穆勒氏激素和多囊卵巢综合征

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摘要

Anti-Mullerian hormone (AMH) is expressed by the granulosa cells of the pre-antral and small antral follicles in the ovary. It is significantly higher in women with polycystic ovary syndrome (PCOS) due to an increased number of antral follicles and also a higher production per antral follicle. It is postulated to have an inhibitory role in folliculogenesis and may play an important role in the pathophysiology of anovulation associated with PCOS. Measurement of the serum AMH levels is very useful for the identification of PCOS and has been suggested as a diagnostic criterion. An international standardisation of the AMH assay, large population-based studies and a global consensus are needed before its incorporation into routine diagnosis. Serum AMH levels add significant value to the clinical markers for the prediction of hyperresponse to controlled ovarian stimulation for in vitro fertilisation treatment and development of ovarian hyperstimulation syndrome. (C) 2016 Published by Elsevier Ltd.
机译：抗Mullerian激素（AMH）由卵巢前，前和小窦卵泡的颗粒细胞表达。多囊卵巢综合症（PCOS）妇女的这一比例明显更高，这是由于其窦房滤泡的数量增加以及每个窦房滤泡的产量更高。假定它在卵泡形成中具有抑制作用，并且可能在与PCOS相关的无排卵的病理生理中起重要作用。血清AMH水平的测量对于PCOS的鉴定非常有用，并已被建议作为诊断标准。在将AMH分析纳入常规诊断之前，需要对其进行国际标准化，进行大量基于人群的研究并获得全球共识。血清AMH水平为预测受精卵的体外受精治疗和卵巢过度刺激综合征发展的反应过度对临床指标具有重要意义。 （C）2016由Elsevier Ltd.出版

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