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Key concepts in management of vulvar cancer.

机译:外阴癌治疗中的关键概念。

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Vulvar carcinoma is an uncommon tumor that is seen most often in older women. Subtle symptoms such as pruritus should prompt examination and targeted biopsy in all women as this disease can be successfully treated even in elderly, frail individuals. Vulvar cancer has a bimodal age distribution and is seen in both young and older women with risk factors including human papillomavirus (HPV) infection, smoking, and vulvar skin diseases (i.e., lichen sclerosus). This cancer is staged surgically, with an update in 2009 incorporating prognostic factors. The treatment of vulvar carcinoma has evolved to include more conservative surgical techniques that provide improved cure rates with emphasis on minimizing morbidity. Advanced and metastatic lesions are now treated with chemoradiation which produces substantial cure rates with decreased morbidity. Promising areas of research in vulvar cancer include refinement of sentinel lymph node biopsy, prevention of lymphedema, and preservation of sexual function following treatment.
机译:外阴癌是一种罕见的肿瘤,最常见于老年妇女。诸如瘙痒之类的细微症状应及时对所有妇女进行检查并进行活检,因为即使在年老体弱的人中也可以成功治疗该病。外阴癌具有双峰年龄分布,在年轻妇女和老年妇女中均可见,其危险因素包括人乳头瘤病毒(HPV)感染,吸烟和外阴皮肤病(即地衣性硬化症)。该癌症是外科手术分期,2009年进行了更新,纳入了预后因素。外阴癌的治疗已发展为包括更为保守的外科手术技术,这些技术可提高治愈率,并着重于降低发病率。现在,对晚期和转移性病变进行化学放射治疗,可显着提高治愈率并降低发病率。外阴癌的有前途的研究领域包括完善前哨淋巴结活检,预防淋巴水肿和治疗后保持性功能。

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