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首页> 外文期刊>Best practice & research:Clinical obstetrics & gynaecology >Cryopreservation of oocytes and embryos for fertility preservation for female cancer patients.
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Cryopreservation of oocytes and embryos for fertility preservation for female cancer patients.

机译：冷冻卵母细胞和胚胎，以保留女性癌症患者的生育力。

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摘要

In vitro fertilization and embryo cryopreservation is regarded as the only established method for fertility preservation in female cancer patients. However, a possible delay in treatment of the primary disease due to ovarian stimulation, exposure to supraphysiologic estrogen levels induced by ovarian stimulation, the requirement for a male partner or willingness to use donor sperm for embryo production, legal, ethical, religious issues related to cryopreservation of embryos raise concerns for patients and physicians. Recent improvements achieved with oocyte vitrification have increased the effectiveness of oocyte cryopreservation rendering it a viable option, especially for patients without a male partner. In vitro maturation avoids treatment delay or exposure to increased estradiol levels associated with ovarian stimulation for in vitro fertilization. In vitro maturation combined with embryo or oocyte vitrification provides previously unavailable options for some patients and improves the services provided by a fertility preservation program.
机译：体外受精和胚胎冷冻保存被认为是女性癌症患者唯一保留生育力的方法。但是，由于卵巢刺激，卵巢刺激引起的超生理雌激素水平的暴露，男性伴侣的需求或愿意使用供体精子进行胚胎生产，与法律有关的法律，道德，宗教问题，可能会延迟原发疾病的治疗胚胎的冷冻保存引起了患者和医生的关注。卵母细胞玻璃化取得的最新进展提高了卵母细胞冷冻保存的有效性，使其成为可行的选择，尤其是对于没有男性伴侣的患者。体外成熟避免了治疗延迟或暴露于与卵巢刺激相关的雌二醇水平升高以进行体外受精。体外成熟与胚胎或卵母细胞玻璃化相结合，为某些患者提供了以前无法获得的选择，并改善了生育保护程序所提供的服务。

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