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首页> 外文期刊>FEMS Microbiology Letters >Conversion of Shigella flexneri serotype 2a to serotype Y in a shigellosis patient due to a single amino acid substitution in the protein product of the bacterial glucosyltransferase gtrII gene
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Conversion of Shigella flexneri serotype 2a to serotype Y in a shigellosis patient due to a single amino acid substitution in the protein product of the bacterial glucosyltransferase gtrII gene

机译：在志贺氏菌病患者中，由于细菌葡糖基转移酶gtrII基因蛋白产物中的单个氨基酸取代，将志贺氏菌志贺氏菌血清型2a转化为Y血清型

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摘要

Conversion of serotype from 2a to Y was demonstrated with five Shigella flexneri isolates recovered from an infected patient. When introduced into the serotype Y isolate, the glucosyltransferase (gtr) II gene of the serotype 2a isolate is capable of inducing the conversion from serotype Y to 2a. In contrast, the gtrII of the serotype Y isolate lacks the capacity to change serotype, resulting from a Cys --> Tyr substitution in its predicted protein sequence. The protein product of the gtrII gene was detected. This is the first report of serotype conversion of S. flexneri in humans, and successful detection of the protein product from a gtr gene. (C) 2003 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved. [References: 25]
机译：血清型从2a转化为Y证实了从感染患者中回收的5株志贺氏志贺氏菌分离株。当被引入到血清型Y分离株中时，血清型2a分离株的葡糖基转移酶（gtr）II基因能够诱导从血清型Y到2a的转化。相反，血清型Y分离株的gtrII缺乏改变血清型的能力，这是由于其预测蛋白序列中的Cys-> Tyr取代所致。检测到gtrII基因的蛋白质产物。这是关于人类中弗氏链球菌血清型转化以及成功检测到来自gtr基因的蛋白质产物的首次报道。 （C）2003年欧洲微生物学会联合会。由Elsevier Science B.V.保留所有权利。 [参考：25]

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