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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System.
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Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System.

机译：通过体外受精影响妊娠和活产的可能性的因素的多变量分析：辅助生殖技术诊所结果报告系统协会的分析。

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OBJECTIVE: To evaluate factors predictive of clinical pregnancy and of pregnancy loss from assisted reproductive technology (ART) using data from the Society for Assisted Reproductive Technology database for 2004-2006. DESIGN: Retrospective cohort. SETTING: Clinic-based data. PATIENT(S): The study population included 225,889 fresh embryo transfer cycles using autologous oocytes and partner semen. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Clinical intrauterine gestation (presence of gestational sac) and live birth (>or=22 weeks gestation and >or=300 g birth weight). RESULT(S): Increasing maternal age was significantly associated with a reduced odds of conception and increased fetal loss until 19 weeks gestation, but not with later pregnancy loss. Intracytoplasmic sperm injection (ICSI), assisted hatching, and increasing number of embryos transferred had significant positive effects on the odds of conception and pregnancy continuation through the first trimester, but did not affect the risk of later loss. Blacks, Asians, and Hispanics had significantly lower odds of clinical pregnancy compared with whites. Also compared with whites, Hispanics and Asians had a significantly greater risk of pregnancy loss in the second and third trimesters, and blacks had a significantly greater risk of pregnancy loss in all trimesters. CONCLUSION(S): Certain demographic and ART treatment parameters influenced chance of conception and early pregnancy loss, whereas black race and Hispanic ethnicity were also significantly associated with late pregnancy loss in ART-conceived pregnancies.
机译：目的：使用辅助生殖技术协会数据库（2004-2006）的数据，评估可预测临床妊娠和辅助生殖技术（ART）导致的妊娠流失的因素。设计：回顾性队列。单位：基于诊所的数据。患者：研究人群包括使用自体卵母细胞和伴侣精液的225,889个新鲜胚胎移植周期。干预措施：无。主要观察指标：临床子宫内妊娠（有妊娠囊）和活产（≥22周妊娠，≥300g出生体重）。结果：孕妇年龄的增长与受孕几率的降低和胎儿流失率的增加显着相关，直到怀孕19周为止，但与以后的妊娠流产没有关系。胞浆内精子注射（ICSI），辅助孵化和转移的胚胎数量增加，对怀孕前三个月的受孕几率和继续妊娠有明显的积极影响，但不影响后期流产的风险。与白人相比，黑人，亚洲人和西班牙裔人的临床妊娠几率显着降低。此外，与白人相比，西班牙裔和亚洲人在孕中期和中期妊娠丢失的风险明显更高，而黑人在所有孕中期都有较高的妊娠丢失风险。结论：某些人口统计学和抗逆转录病毒治疗参数影响了受孕的机会和早孕流产，而黑人和西班牙裔人也与接受ART的怀孕中的晚孕流产显着相关。

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