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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis.
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Mucuna pruriens improves male fertility by its action on the hypothalamus-pituitary-gonadal axis.

机译：Mucuna pruriens通过作用于下丘脑-垂体-性腺轴来改善男性的生育能力。

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OBJECTIVE: To understand the mechanism of action of Mucuna pruriens in the treatment of male infertility. DESIGN: Prospective study. SETTING: Departments of Biochemistry, Urology, and Obstetrics and Gynecology, C.S.M. Medical University, Lucknow, India. PATIENT(S): Seventy-five normal healthy fertile men (controls) and 75 men undergoing infertility screening. INTERVENTION(S): High-performance liquid chromatography assay for quantitation of dopa, adrenaline, and noradrenaline in seminal plasma and blood. Estimation by RIA of hormonal parameters in blood plasma, namely T, LH, FSH, and PRL. MAIN OUTCOME MEASURE(S): Before and after treatment, serum T, LH, FSH, PRL, dopamine, adrenaline, and noradrenaline in seminal and blood plasma were measured. RESULT(S): Decreased sperm count and motility were seen in infertile subjects. Serum T and LH levels, as well as seminal plasma and blood levels of dopamine, adrenaline, and noradrenaline were also decreased in all groups of infertile men. This was accompanied by significantly increased serum FSH and PRL levels in oligozoospermic subjects. Treatment with M. pruriens significantly improved T, LH, dopamine, adrenaline, and noradrenaline levels in infertile men and reduced levels of FSH and PRL. Sperm count and motility were significantly recovered in infertile men after treatment. CONCLUSION(S): Treatment with M. pruriens regulates steroidogenesis and improves semen quality in infertile men.
机译：目的：了解毛豆M（Mucuna pruriens）治疗男性不育症的作用机制。设计：前瞻性研究。地点：中国医学科学院生物化学，泌尿外科和妇产科。印度拉克瑙的医科大学。患者：75名正常健康的可育男性（对照）和75名接受不育检查的男性。干预：高效液相色谱分析法，用于定量检测精浆和血液中的多巴，肾上腺素和去甲肾上腺素。通过RIA估算血浆中的激素参数，即T，LH，FSH和PRL。主要观察指标：治疗前后，对精浆和血浆中的血清T，LH，FSH，PRL，多巴胺，肾上腺素和去甲肾上腺素进行测定。结果：在不育症患者中观察到精子数量减少和运动能力下降。在所有不育男性组中，血清T和LH水平以及多巴胺，肾上腺素和去甲肾上腺素的精浆和血液水平也降低。这伴随着少精子症患者血清FSH和PRL水平的显着增加。瘙痒分支杆菌的治疗可显着改善不育男性的T，LH，多巴胺，肾上腺素和去甲肾上腺素水平，并降低FSH和PRL水平。治疗后不育男性的精子数量和运动能力明显恢复。结论：瘙痒分支杆菌治疗可调节不育男性的类固醇生成并改善精液质量。

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