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首页> 外文期刊>Fertility and Sterility: Official Journal of the American Fertility Society, Pacific Coast Fertility Society, and the Canadian Fertility and Andrology Society >Serum anti-Mullerian hormone and inhibin B concentrations are not useful predictors of ovarian response during ovulation induction treatment with recombinant follicle-stimulating hormone in women with polycystic ovary syndrome.
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Serum anti-Mullerian hormone and inhibin B concentrations are not useful predictors of ovarian response during ovulation induction treatment with recombinant follicle-stimulating hormone in women with polycystic ovary syndrome.

机译：在患有多囊卵巢综合征的女性中，用重组促卵泡激素进行排卵诱导治疗时，血清抗苗勒管激素和抑制素B的浓度不是卵巢反应有用的预测指标。

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OBJECTIVE: To describe changes of anti-Mullerian hormone (AMH) and inhibin B during low-dose gonadotropin ovulation induction (OI) treatment in women with polycystic ovary syndrome (PCOS), and thus disturbed selection of the dominant follicle. DESIGN: Observational study. SETTING: A referral fertility clinic. PATIENT(S): Women with PCOS (n = 48) and normo-ovulatory women (n = 23). INTERVENTION(S) AND MAIN OUTCOME MEASURE(S): Serum AMH, inhibin B, FSH, and E(2) concentrations were measured at start of stimulation, on the day of follicle selection, and at administration of hCG during OI cycles and were compared with concentration measured during the normal menstrual cycle. RESULT(S): Development of a single dominant follicle was observed in 92% of all OI cycles, reflected by similar E(2) concentrations compared with those in spontaneous cycles. AMH concentrations were constant during low-dose ovarian stimulation. Inhibin B concentrations remained elevated in patients with PCOS, suggesting prolonged survival of small antral follicles, whereas in controls inhibin B concentrations declined during the late follicular phase. CONCLUSION(S): The lack of change in AMH and inhibin B concentrations suggest that follicle dynamics during low-dose stimulation seem different from those during controlled ovarian hyperstimulation. In addition, constant AMH and inhibin B levels suggest that neither AMH nor inhibin B is an accurate marker of ovarian response after low-dose gonadotropin OI in patients with PCOS.
机译：目的：描述多囊卵巢综合征（PCOS）妇女在低剂量促性腺激素排卵（OI）治疗期间抗Mullerian激素（AMH）和抑制素B的变化，从而扰乱优势卵泡的选择。设计：观察性研究。地点：转诊生育诊所。患者：患有PCOS的女性（n = 48）和排卵正常的女性（n = 23）。干预和主要观察指标：在刺激开始，卵泡选择当天以及在OI周期中给予hCG时，测量血清AMH，抑制素B，FSH和E（2）的浓度，与正常月经周期测得的浓度相比。结果：在所有OI周期的92％中观察到单个优势卵泡的发育，这与自发周期的E（2）浓度相近。在低剂量卵巢刺激过程中，AMH浓度恒定。 PCOS患者中抑制素B的浓度仍保持较高水平，表明小窦囊的存活时间延长，而在对照组中，抑制素B的浓度在卵泡晚期下降。结论：AMH和抑制素B浓度没有变化，表明低剂量刺激过程中的卵泡动力学似乎与控制性卵巢过度刺激过程中的卵泡动力学不同。此外，恒定的AMH和抑制素B水平表明，对于PCOS患者，小剂量促性腺激素OI后，AMH和抑制素B都不是卵巢反应的准确标志。

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