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首页> 外文期刊>Fitoterapia >The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system
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The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system

机译：八角茴香（Pimpinella anisum，L.）精油对中枢神经系统药物作用的影响

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摘要

Anise (Pimpinella anisum L; Apiaceae) and its essential oil have been widely used in folk medicine, pharmacy and food industry. Since there are some data about the impact of anise on functions of central nervous system (CNS), the issue of possible interactions with drugs acting in CNS should be considered. This survey aimed to examine the influence of aniseed essential oil (EO) intake on the effects of drugs that act in CNS. The chemical profile of essential oil determined by GC-MS revealed as the main components: trans-anethole (88.49%), gamma-himachalene (3.13%), cis-isoeugenol (1.99%), and linalool (1.79%). The effects of codeine, diazepam, midazolam, pentobarbital, imipramine and fluoxetine were tested in mice after 5 days of peroral pretreatment with human equivalent dose of aniseed EO (0.3 mg/kg). The intake of EO led to significant increase of analgesic effect of codeine. The motor impairment caused by midazolam was enhanced in the group treated by EO. The application of diazepam decreased the number and percentage of entries in open arm in elevated maze plus test in the group pretreated with EO indicating augmented effect of drug on motor activity. EO pretreatment caused significant shortage of pentobarbital induced sleeping time when compared to control. The decrease in antidepressant effect of imipramine and fluoxetine was diminished by the pretreatment with aniseed EO. Based on the results of this study we conclude that concomitant intake of aniseed EO preparations and drugs that act on CNS should be avoided due to potential herb-drug interactions, which also need further clinical confirmation
机译：茴香（Pimpinella anisum L; Apiaceae）及其精油已被广泛用于民间医学，制药和食品工业。由于有关于茴香对中枢神经系统（CNS）功能影响的一些数据，应考虑与作用于CNS的药物可能相互作用的问题。这项调查旨在检验茴香精油（EO）摄入量对中枢神经系统药物作用的影响。通过GC-MS测定的精油化学成分为主要成分：反式茴香脑（88.49％），γ-喜马林烯（3.13％），顺式异丁香酚（1.99％）和芳樟醇（1.79％）。经人类等剂量大茴香油（0.3 mg / kg）经口预处理5天后，在小鼠中测试了可待因，地西epa，咪达唑仑，戊巴比妥，丙咪嗪和氟西汀的作用。 EO的摄入导致可待因的止痛作用显着增加。在EO治疗组中，由咪达唑仑引起的运动障碍加剧。在用EO预处理的组中，地西epa的应用减少了迷宫升高试验中张开臂的进入次数和百分比，这表明药物对运动活动的增强作用。与对照相比，EO预处理导致戊巴比妥诱发的睡眠时间明显不足。茴香油预处理可降低丙咪嗪和氟西汀的抗抑郁作用。根据这项研究的结果，我们得出结论，由于潜在的草药-药物相互作用，应避免同时摄入八角茴香油制剂和作用于中枢神经系统的药物，这也需要进一步的临床确认

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