Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

Liu Rui; Zhang JingZhao; Liu WenCong; Kimura Yoshiyuki; Zheng YiNan

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Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

机译：从高脂饮食喂养的西洋参叶中分离出的人参皂甙类人参皂苷对肥胖的抗肥胖作用

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Effects of protopanaxdiol (PDG) and protopanaxatriol (PTG) types of ginsenosides isolated from the leaves of American ginseng on porcine pancreatic lipase activity were determined in vitro. PDG inhibited the pancreatic lipase activity in a dose-dependent manner at the concentrations of 0.25-1 mg/ml. It inhibited hydrolysis of about 83.2% of triolein at about 1 mg/ml of PDG. However, PTG showed no inhibitory activity. Therefore, anti-obesity activity of PDG was evaluated in mice fed a high-fat diet. The results demonstrated that PDG was effective in preventing and healing obesity, fatty liver and hypertriglyceridemia in mice fed with a high-fat diet

机译：从人参叶片中分离出人参皂苷的原人参二醇（PDG）和原人参三醇（PTG）类型对猪胰脂肪酶活性的影响。 PDG在0.25-1 mg / ml的浓度下以剂量依赖的方式抑制胰腺脂肪酶的活性。在约1 mg / ml的PDG时，它抑制了约83.2％的三油精水解。然而，PTG没有显示抑制活性。因此，在饲喂高脂饮食的小鼠中评估了PDG的抗肥胖活性。结果表明，PDG可有效预防和治疗高脂饮食小鼠的肥胖，脂肪肝和高甘油三酯血症

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《Fitoterapia》 |2010年第8期|共9页
作者
Liu Rui; Zhang JingZhao; Liu WenCong; Kimura Yoshiyuki; Zheng YiNan;
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正文语种 eng
中图分类林区药材;
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triolein: 122-32-7; porcine pancreatic lipase; Panax quinquefolius stem/leaf derived protopanaxatriol type ginsenosides: enzyme inhibitor-drug; met; Panax quinquefolius stem/leaf derived protopanaxdiol type ginsenosides: enzyme inhibitor-drug; gastr; high-fat diet; enzyme activity; dose-dependent manner; hydrolysis inhibition;

机译：三油酸甘油酯：122-32-7;猪胰脂肪酶;西洋参茎/叶衍生的原人参三醇型人参皂苷：met;西洋参茎叶/叶片衍生的原人参二醇型人参皂苷：酶抑制剂-药物;胃泌素;高脂饮食酶活性剂量依赖性水解抑制;

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1. Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet [J] . Liu Rui, Zhang JingZhao, Liu WenCong, Fitoterapia . 2010,第8期

机译：从高脂饮食喂养的西洋参叶中分离出的人参皂甙类人参皂苷对肥胖的抗肥胖作用
2. Variable effects of American ginseng: a batch of American ginseng (Panax quinquefolius L.) with a depressed ginsenoside profile does not affect postprandial glycemia. [J] . Sievenpiper JL, Arnason JT, Leiter LA, European journal of clinical nutrition . 2003,第2期

机译：西洋参的可变作用：一批人参皂苷含量低的西洋参（Panax quinquefolius L.）不会影响餐后血糖。
3. Comparative analysis of ginsenosides in different growth ages and parts of Asian ginseng ( Panax ginseng C.A. Meyer) and American ginseng ( Panax quinquefolius L.) [J] . Yanwen Yang, Yuantong Jiang, Lianxue Zhang Bangladesh Journal of Botany . 2017,第4期

机译：人参皂苷在不同生长年龄和亚洲人参（Panax ginseng C.A. Meyer）和西洋参（Panax quinquefolius L.）的部分中的比较分析
4. Stimulatory Effects of Extracts Prepared from Salix babylonica L. on Fat Catabolism in Mice Fed High-fat Diet [C] . Ke-yue LIU ICEEP 2012 . 2012

机译：Salix Babylonica L的刺激作用。大鼠高脂饮食小鼠脂肪分解代谢的刺激作用
5. Genetic characterization, ginsenoside analysis and micropropagation of American ginseng (Panax quinquefolius L.). [D] . Obae, Samuel G. 2010

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6. Cold-induced ginsenosides accumulation is associated with the alteration in DNA methylation and relative gene expression in perennial American ginseng (Panax quinquefolius L.) along with its plant growth and development process [O] . Mengzhen Hao, Yuhang Zhou, Jinhui Zhou, 2020

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7. Comparing Ginsenoside Production in Leaves and Roots of Wild American Ginseng (Panax quinquefolius) [O] . James Matthew Searels, Karissa D. Keen, Jonathan L. Horton, 2013

机译：比较野生西洋参（ Panax quinquefolius ）的叶片和根中的人参皂甙产量

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3. A stable high ginsenoside-yielding callus line of Panax Quinquefolium (American ginseng) and a method for developing such stable high ginsenoside-yielding callus line of Panax Quinquefolium [P] . 外国专利： KR100404314B1 . 2003-11-03

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4. STABLE HIGH GINSENOSIDE-YIELDING CALLUS LINE OF PANAX QUINQUEFOLIUM (AMERICAN GINSENG) AND A METHOD FOR DEVELOPING SUCH STABLE HIGH GINSENOSIDE-YIELDING CALLUS LINE OF PANAX QUINQUEFOLIUM [P] . 外国专利： KR20010047849A . 2001-06-15

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5. Stable high ginsenoside-yielding callus line of Panax quinquefolium (American ginseng) and a method for developing such stable high ginsenoside-yielding callus line [P] . 外国专利： US6326202B1 . 2001-12-04

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Anti-Obesity effects of protopanaxdiol types of Ginsenosides isolated from the leaves of American ginseng (Panax quinquefolius L.) in mice fed with a high-fat diet

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