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首页> 外文期刊>Fitoterapia >Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats
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Comparative pharmacokinetics and bioavailability studies of quercetin, kaempferol and isorhamnetin after oral administration of Ginkgo biloba extracts, Ginkgo biloba extract phospholipid complexes and Ginkgo biloba extract solid dispersions in rats

机译:口服银杏叶提取物,银杏叶提取物磷脂复合物和银杏叶提取物固体分散体后,槲皮素,山奈酚和异鼠李素的比较药代动力学和生物利用度研究

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The aim of this study was to improve the oral bioavailability of Ginkgo biloba extract (GBE) through preparing G. biloba extract phospholipid complexes (GBP) and G. biloba extract solid dispersions (CBS). Firstly we prepared the GBP and GBS and studied their physicochemical properties by differential scanning calorimetry (DSC), powder X-ray diffraction (XRD) and dissolution. Then we studied the pharmacokinetic characteristics and bioavailability in rats. The results showed that the bioavailability of quercetin, kaempferol and isorhamnetin in rats was increased remarkably after oral administration of GBP and GBS comparing with GBE. The bioavailabilities of GBP increased more than that of GBS
机译:这项研究的目的是通过制备银杏叶提取物磷脂复合物(GBP)和银杏叶提取物固体分散体(CBS)来提高银杏叶提取物(GBE)的口服生物利用度。首先,我们制备了GBP和GBS,并通过差示扫描量热法(DSC),粉末X射线衍射(XRD)和溶解研究了它们的理化性质。然后,我们研究了大鼠的药代动力学特征和生物利用度。结果表明,与GBE相比,GBP和GBS口服后,槲皮素,山奈酚和异鼠李素的生物利用度显着提高。 GBP的生物利用度比GBS的增加

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