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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats.
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Protective effect of fermented sea tangle against ethanol and carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats.

机译：发酵海藻对乙醇和四氯化碳诱导的Sprague-Dawley大鼠肝损伤的保护作用。

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摘要

Sea tangle has long been used as Korean folk remedy to promote material health, and is one of the popular dietary supplement. This study was designed to evaluate the protective effect of fermented sea tangle (FST) against ethanol and carbon tetrachloride (CCl(4))-induced hepatotoxicity in rats. Sprague-Dawley rats were orally treated with FST (25, 250, 2500 mg/kg/day) with administration of ethanol (5 mL/kg) for 13 weeks and the single intraperitoneal (i.p.) dose of 50% CCl(4) (5 mL/kg/day, CCl(4) in olive oil) at 12 week, and repeated i.p. dose of 20% CCl(4) (2 mL/kg/day) for 1 week. Hepatotoxicity was evaluated by measuring the serum levels of glutamic pyruvate transaminase (GPT), gamma glutamyl transpeptidase (gamma-GT) and malondialdehyde (MDA) as well as the tissue levels of antioxidant enzyme such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Ethanol and CCl(4)-induced the rat liver damage, and significantly increased (p<0.05) the GPT, gamma-GT and MDA levels, and decreased the SOD, CAT and GPx levels. However, treatment with FST could decrease serum GPT, gamma-GT, and MDA levels significantly in plasma, and increase the activities of SOD, CAT, and GPx in liver tissues compared with ethanol and CCl(4)-treated group.
机译：长期以来，海参一直被用作韩国民间疗法以促进身体健康，并且是流行的膳食补充剂之一。这项研究旨在评估发酵的海纠缠（FST）对大鼠乙醇和四氯化碳（CCl（4））诱导的肝毒性的保护作用。使用FST（25、250、2500 mg / kg /天）口服Sprague-Dawley大鼠，给予乙醇（5 mL / kg）持续13周，腹膜内（ip）剂量为50％CCl（4）（ 5周/公斤/天，在橄榄油中加入CCl（4）（12周），然后重复腹膜内注射剂量为20％CCl（4）（2 mL / kg /天），持续1周。通过测量血清谷氨酸丙酮酸转氨酶（GPT），γ谷氨酰转肽酶（γ-GT）和丙二醛（MDA）以及抗氧化剂酶（例如超氧化物歧化酶（SOD），过氧化氢酶（CAT））的组织水平来评估肝毒性和谷胱甘肽过氧化物酶（GPx）。乙醇和CCl（4）诱导大鼠肝损伤，并显着增加（p <0.05）GPT，γ-GT和MDA水平，并降低SOD，CAT和GPx水平。但是，与乙醇和CCl（4）处理组相比，FST治疗可以显着降低血浆中的血清GPT，γ-GT和MDA水平，并增加肝脏组织中SOD，CAT和GPx的活性。

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