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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Bamboo salt reduces allergic responses by modulating the caspase-1 activation in an OVA-induced allergic rhinitis mouse model
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Bamboo salt reduces allergic responses by modulating the caspase-1 activation in an OVA-induced allergic rhinitis mouse model

机译：竹盐通过调节OVA诱导的变应性鼻炎小鼠模型中的caspase-1激活来减少变应性反应

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摘要

Bamboo salt (BS) is a specially processed salt according to the traditional recipe using sun-dried salt (SDS) and bamboo in Korea. The present study investigated the effects and mechanism of BS, SDS, NaCl, or mineral mixture (containing zinc, magnesium, and potassium) on ovalbumin (OVA)-induced allergic rhinitis (AR) animal model. The increased number of rubs was inhibited by the oral administration of BS, SDS, NaCl, mineral mixture, or nose inhalation of BS. The increased levels of IgE, histamine, and interleukin (IL)-1β in serum were reduced by BS. The level of interferon-γ was increased, whereas the level of IL-4 was reduced on the spleen tissue of BS-treated mice. In the BS-treated mice, the number of eosinophils and mast cells infiltration increased by OVA-sensitization were also decreased. Protein levels of inflammatory cytokines were reduced by BS or NaCl administration in the nasal mucosa of the AR mice. In addition, BS inhibited caspase-1 activity in the nasal mucosa tissue. In activated human mast cells, BS significantly inhibited the production of IL-1β and thymic stromal lymphopoietin and activation of caspase-1. Our data indicate that BS has anti-allergic and anti-inflammatory effects by regulating of caspase-1 activation in AR mice and in vitro models.
机译：竹盐（BS）是在韩国根据传统配方使用晒干盐（SDS）和竹子进行特殊加工的盐。本研究调查了BS，SDS，NaCl或矿物质混合物（含锌，镁和钾）对卵白蛋白（OVA）诱发的变应性鼻炎（AR）动物模型的影响及其机理。口服BS，SDS，NaCl，矿物质混合物或鼻吸入BS可以抑制摩擦次数的增加。 BS可降低血清中IgE，组胺和白介素（IL）-1β的水平升高。在BS处理的小鼠的脾脏组织中，干扰素-γ的水平升高，而IL-4的水平降低。在BS处理的小鼠中，OVA致敏增加的嗜酸性粒细胞和肥大细胞浸润的数量也减少了。通过在AR小鼠的鼻黏膜中进行BS或NaCl给药，炎性细胞因子的蛋白水平降低。此外，BS抑制了鼻黏膜组织中的caspase-1活性。在激活的人类肥大细胞中，BS显着抑制IL-1β和胸腺基质淋巴细胞生成素的产生以及caspase-1的激活。我们的数据表明，BS通过调节AR小鼠和体外模型中的caspase-1激活具有抗过敏和抗炎作用。

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