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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Safety assessment of dietary administered paprika color in combined chronic toxicity and carcinogenicity studies using F344 rats.
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Safety assessment of dietary administered paprika color in combined chronic toxicity and carcinogenicity studies using F344 rats.

机译：在使用F344大鼠进行的慢性毒性和致癌性联合研究中，饮食中施用的辣椒粉颜色的安全性评估。

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Combined chronic toxicity and carcinogenicity studies of paprika color, used as a food additive in various countries, were performed in male and female F344 rats. Dietary concentrations of 0%, 0.62%, 1.25%, 2.5% and 5% were applied in a 52-week toxicity study and 0%, 2.5% and 5% in a 104-week carcinogenicity study. Treatment with paprika color caused a significant increase in incidence of hepatocellular vacuolation in 5% males, but no toxicological effects were found with reference to survival rates, body weights, hematological or serum biochemical parameters and organ weights at any dose level in either sex in the chronic toxicity study. Also, paprika color did not induce specific tumors nor did it exert significant influence on the development of spontaneous tumors in any of the organs examined in the carcinogenicity study. In conclusion, based on slight histopathological changes observed in 5% male livers, the no-observed-effect level (NOEL) was estimated to be 2.5% in the diet (1,253 mg/kg bw/day) and the no-observed-adverse-effect level (NOAEL) was determined to be 5% in the diet (2,388 mg/kg bw/day) for male rats, and for females, the NOEL was concluded to be 5% in the diet (2,826 mg/kg bw/day). Additionally, paprika color was not carcinogenic to male and female F344 rats under the present experimental conditions.
机译：在雄性和雌性F344大鼠中进行了辣椒粉颜色的慢性毒性和致癌性的综合研究，该辣椒粉颜色在不同国家被用作食品添加剂。在52周的毒性研究中采用0％，0.62％，1.25％，2.5％和5％的饮食浓度，在104周的致癌性研究中采用0％，2.5％和5％的饮食浓度。辣椒粉颜色的治疗引起5％男性肝细胞空泡发生率显着增加，但是在任何剂量水平下，无论成活率，体重，血液学或血清生化参数以及器官重量，均未发现毒理学作用。慢性毒性研究。同样，辣椒粉的颜色也不会诱发特定的肿瘤，也不会对致癌性研究中检测到的任何器官的自发性肿瘤产生显着影响。总之，根据在5％男性肝脏中观察到的轻微组织病理学变化，饮食中的未观察到的影响水平（NOEL）估计为2.5％（1,253 mg / kg bw /天），而未观察到的不良反应是雄性大鼠日粮（2,388 mg / kg bw /天）的NOEL水平确定为5％，而雌性日粮（2,826 mg / kg bw /天）的NOEL结论为5％天）。另外，在当前的实验条件下，辣椒粉的颜色对雄性和雌性F344大鼠没有致癌性。

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