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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges
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A retrospective analysis of allergic reaction severities and minimal eliciting doses for peanut, milk, egg, and soy oral food challenges

机译：花生，牛奶，鸡蛋和大豆口服食品挑战的过敏反应严重程度和最低引致剂量的回顾性分析

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摘要

Food allergy is a public health concern, affecting up to 6% of children and 2% of adults. The severity of allergic reactions can range from mild to potentially life-threatening. In addition, the minimum amount of protein needed to provoke an allergic reaction in an individual patient (the minimal eliciting dose (MED)) ranges from a few micrograms to several grams. To determine whether a retrospective analysis of published data from oral food challenges could be used to assess the potential relationship between MEDs and reaction severities at the MEDs, a three class (mild, moderate, severe) reaction grading system was developed by integrating previously published reaction grading systems. MEDs and symptoms were collected from food challenge studies and each reaction was graded using the integrated grading system. Peanut allergic patients who experienced severe reactions had significantly higher MEDs and threshold distribution doses than those who experienced mild and moderate reactions. No significant differences in threshold distributions according to the severity grading were found for milk, egg and soy. The relationship between threshold dose distribution and reaction severity based on these grading criteria differed between peanut and other allergens, and severe reactions were found to occur in some patients at low MEDs for all of these food allergens. Published by Elsevier Ltd.
机译：食物过敏是公共卫生问题，影响多达6％的儿童和2％的成年人。过敏反应的严重程度从轻度到可能危及生命。另外，在单个患者中引起过敏反应所需的最小蛋白质量（最小引发剂量（MED））为几微克至几克。为了确定是否可以对口服食品挑战的已发表数据进行回顾性分析，以评估MED与MED的反应严重程度之间的潜在关系，通过整合先前发表的反应，开发了三类（轻度，中度，重度）反应分级系统分级系统。从食物挑战研究中收集MED和症状，并使用综合评分系统对每个反应进行评分。发生严重反应的花生过敏患者的MEDs和阈值分布剂量明显高于发生轻度和中度反应的花生过敏患者。对于牛奶，鸡蛋和大豆，根据严重程度分级，阈值分布没有显着差异。在花生和其他过敏原之间，基于这些分级标准的阈值剂量分布与反应严重性之间的关系有所不同，并且发现在所有这些食物过敏原的低MED下，一些患者发生严重反应。由Elsevier Ltd.发布

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