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首页> 外文期刊>Food and Chemical Toxicology: An International Journal Published for the British Industrial Biological Research >Scientific evaluation of the chronic toxicity of the herbal medicine CGX in beagle dogs.
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Scientific evaluation of the chronic toxicity of the herbal medicine CGX in beagle dogs.

机译：科学评估中草药CGX对比格犬的慢性毒性。

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摘要

CGX is a potential hepatoprotective herbal medicine used to treat various chronic liver disorders. The purpose of the study was to evaluate the pharmaceutical safety of CGX via a systemic 13-week repeated dose toxicity test in beagle dogs. Male and female beagle dogs were divided into four groups and two animals each from the control and high-dose group (400 mg/kg) were allocated into recovery groups. The dogs were administered with CGX (0, 100, 200, 400 mg/kg) for 13 weeks. During the experimental period, the dogs were observed for signs of gross toxicity and for behavioral changes; body weight and food consumption were measured. An ophthalmologic examination and urinalysis were performed at 0 and 13th week and blood biochemistry and hematological parameters analyses were performed at 0, 6th, and 13th week. A histopathological examination was also performed at the end of the experiment. There were no CGX-induced abnormalities in clinical signs, organ weights, food consumption, hematological, urine, and blood biochemical parameters, or histopathological findings in any of the groups during or after the 13 weeks. We demonstrated the safety of CGX for 13-week repeated dose and considered that it is safe for chronic clinical use.
机译：CGX是一种潜在的保护肝脏的草药，可用于治疗各种慢性肝脏疾病。该研究的目的是通过在比格犬中进行的为期13周的全身性重复剂量毒性试验评估CGX的药物安全性。将雄性和雌性比格犬分为四组，将对照组和高剂量组（400 mg / kg）的两只动物分别分为恢复组。给犬施用CGX（0、100、200、400 mg / kg），持续13周。在实验期间，观察到这些狗的总毒性迹象和行为改变。测量体重和食物消耗。在第0周和第13周进行眼科检查和尿液分析，并在第0周，第6周和第13周进行血液生化和血液学参数分析。在实验结束时也进行了组织病理学检查。在13周内或之后，任何组均没有CGX引起的临床体征，器官重量，食物消耗，血液，尿液和血液生化参数或组织病理学发现异常。我们证明了CGX对于13周重复剂量的安全性，并认为对于慢性临床使用是安全的。

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