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Spatial-temporal Distribution of the 2007 Melamine-assodated Nephrotoxic Renal Failure Outbreak among Pets and Factors Associated with Pet Survival

机译:2007年三聚氰胺相关的肾毒性肾衰竭暴发在宠物中的时空分布及与宠物生存相关的因素

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This study describes the spatial-temporal distribution of the 2007 melamine-associated nephrotoxic renal failure outbreak among pets and factors associated with pet survival. A retrospective case series was performed using melamine-associated consumercomplaint data obtained from United States (U.S.) Food and Drug Administration. Data represented 10,109 pets (5,284 dogs and 4,408 cats). Spatial-temporal distributions and factors associated with pet characteristics and survival were analyzed using Epilnfo version 3.2 and SAS version 9.2. Overall, 194 pet food brands were allegedly contaminated with melamine, with seven major brands affecting 71% of the pets. The reports were received between March and July, 2007 and came from all 50 states. The samepercentage of pet deaths (45%) was observed in cats and dogs. Kidney failure was the commonest (27%) clinical sign reported. Pet survival was significantly (P< 0.05) associated with region, reported renal failure, hospitalization, and interaction betweenregion and period of case reporting. Pets hospitalized and those without reported renal failure were 1.2 and 1.3 times more likely to survive than those not hospitalized (OR, 1.22; 95% CI, 1.08,1.39, P< 0.0020) and those with renal failure (OR, 1.27; 95% CI, 1.09, 1.47, P< 0. 0016), respectively. Overall, pets from the Northeast and the South were more likely to survive than those from the Midwest or West, particularly during the first period of case reporting. Survival was not influenced by pet species or pet food brands. Using the FDA consumer complaints surveillance data, this study describes the spatial-temporal distribution of reported melamine-associated nephrotoxicity among cats and dogs during 2007 in the U.S. and identifies variables associated with survival of affected pets.
机译:这项研究描述了宠物中2007年三聚氰胺相关的肾毒性肾衰竭暴发的时空分布以及与宠物存活相关的因素。使用从美国食品药品监督管理局获得的与三聚氰胺相关的消费者投诉数据进行回顾性病例系列研究。数据代表10,109只宠物(5,284只狗和4,408只猫)。使用Epilnfo 3.2版和SAS 9.2版分析了与宠物特征和生存相关的时空分布和因素。总体而言,据称有194个宠物食品品牌被三聚氰胺污染,其中七个主要品牌影响了71%的宠物。报告是在2007年3月至7月之间收到的,来自所有50个州。在猫和狗中观察到相同比例的宠物死亡(45%)。肾衰竭是最常见的临床体征(27%)。宠物存活率与地区,报告的肾衰竭,住院以及地区和病例报告期间之间的相互作用显着相关(P <0.05)。住院和未报告肾功能衰竭的宠物的存活率分别为未住院的患者(OR,1.22; 95%CI,1.08,1.39,P <0.0020)和肾衰竭的患者(OR,1.27; 95% CI,1.09、1.47,P <0.0016)。总体而言,东北和南部的宠物比中西部或西部的宠物更有可能生存,尤其是在病例报告的第一阶段。生存不受宠物种类或宠物食品品牌的影响。本研究使用FDA消费者投诉监测数据,描述了2007年美国猫和狗中已报告的三聚氰胺相关肾毒性的时空分布,并确定了与受影响宠物的生存相关的变量。

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