Re: 'cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: Multi-institutional phase II trial.' - Proposal of a clinical trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer, the CHORINE study.

AnsaloniL.; DeIacoP.; FrigerioL.

首页> 外文期刊>Gynecologic Oncology: An International Journal >Re: 'cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: Multi-institutional phase II trial.' - Proposal of a clinical trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer, the CHORINE study.

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Re: 'cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: Multi-institutional phase II trial.' - Proposal of a clinical trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer, the CHORINE study.

机译：回复：“细胞减灭术和腹膜内高温化疗作为晚期上皮性卵巢癌的前期治疗：多机构II期临床试验。” -有关CHORINE研究的一项针对晚期卵巢癌的细胞减灭术和腹膜高温化疗的临床试验的建议。

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We read with great interest the article by Deraco et al. [1 ] reporting the results of a multicenter phase II trial using cytoreductive surgery (CRS) and closed-abdomen hyperthermic intraoperative peritoneal chemotherapy (HIPEC) with cisplatin and doxorubicin in front-line treatment of epithelial ovarian cancer (EOC). The authors accrued 26 patients over 6 years in four different Italian centers, achieving macro-scopically complete cytoreduction in 15 patients and only minimal residual disease (<2.5mm) in the remaining 11. Although major complications occurred in four patients, including one postoperative death, 25 of the 26 patients started systemic chemotherapy within a median of 46 days after surgery and noticeable five-year overall survival (60.7%) and progression-free survival (15.2%) have been obtained.

机译：我们非常感兴趣地阅读了Deraco等人的文章。 [1]报告了一项多中心的II期临床试验的结果，该试验使用了细胞减灭术（CRS）和闭腹高温术中腹腔化疗（HIPEC）顺铂和阿霉素治疗一线性上皮性卵巢癌（EOC）。作者在意大利的四个不同中心进行了为期6年的26位患者的研究，在15位患者中实现了宏观上完整的细胞减少，其余11位仅实现了最小的残留疾病（<2.5mm）。尽管四位患者发生了严重并发症，包括一名术后死亡。，在这26名患者中，有25名在手术后的46天中位数开始了全身化疗，并且获得了显着的五年总生存率（60.7％）和无进展生存率（15.2％）。

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《Gynecologic Oncology: An International Journal》 |2012年第1期|共3页
作者
AnsaloniL.; DeIacoP.; FrigerioL.;
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原文格式 PDF
正文语种 eng
中图分类肿瘤学;
关键词
Cytoreductive surgery; Epithelial ovarian cancer; Hyperthermic intraperitoneal chemotherapy;

机译：细胞减灭术;上皮性卵巢癌;腹膜热化学疗法;

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1. Re: "cytoreductive surgery and hyperthermic intraperitoneal chemotherapy as upfront therapy for advanced epithelial ovarian cancer: Multi-institutional phase II trial." - Proposal of a clinical trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in advanced ovarian cancer, the CHORINE study. [J] . AnsaloniL., DeIacoP., FrigerioL. Gynecologic Oncology: An International Journal . 2012,第1期

机译：回复：“细胞减灭术和腹膜内高温化疗作为晚期上皮性卵巢癌的前期治疗：多机构II期临床试验。” -有关CHORINE研究的一项针对晚期卵巢癌的细胞减灭术和腹膜高温化疗的临床试验的建议。
2. Hyperthermic intraperitoneal chemotherapy after extensive cytoreductive surgery in patients with primary advanced epithelial ovarian cancer: interim analysis of a phase II study. [J] . Lim MC, Kang S, Choi J Annals of surgical oncology . 2009,第4期

机译：原发性晚期上皮性卵巢癌患者进行大量细胞还原手术后的腹膜内高温化疗：II期研究的中期分析。
3. Hyperthermic Intraperitoneal Chemotherapy After Extensive Cytoreductive Surgery in Patients with Primary Advanced Epithelial Ovarian Cancer: Interim Analysis of a Phase II Study [J] . Myong Cheol Lim MD, Sokbom Kang MD PhD, Jaeho Choi MD, Annals of Surgical Oncology . 2009,第4期

机译：原发性晚期上皮性卵巢癌患者广泛性细胞减少手术后的高温腹膜内化学疗法：II期研究的中期分析
4. Efficacy of Intraperitoneal Perfusion Hyperthermic Chemotheraphy(CHIP)With Cisplatin Combined With Intraveuous Chemotherapy for Patients With Advanced Gastrointestinal Carcinoma [C] . The 3rd Asian congress on hyperthermic oncology and the 9th Chineses symposium on hyperthermic oncology . 2002

机译：腹腔灌注热化学疗法（CHIP）联合顺铂联合静脉化疗治疗晚期胃肠道癌的疗效
5. The Evolution of Hyperthermic Intraperitoneal Chemotherapy in The Setting of Advanced Ovarian Cancer [D] . Quindlen, Kevin J. 2019

机译：高温腹膜内化疗的演变在晚期卵巢癌的环境中
6. Rationale and study design of the CHIPPI-1808 trial: a phase III randomized clinical trial evaluating hyperthermic intraperitoneal chemotherapy (HIPEC) for stage III ovarian cancer patients treated with primary or interval cytoreductive surgery [O] . H. El Hajj, M. Vanseymortier, D. Hudry, 2021

机译：Chippi-1808试验的理由和学习设计：III期随机临床试验评估初级或间隔细胞诊断治疗阶段III卵巢癌患者的高温腹膜内化疗
7. Cytoreductive Surgery plus Hyperthermic Intraperitoneal Chemotherapy to Treat Advanced/Recurrent Epithelial Ovarian Cancer: Results from a Retrospective Study on Prospectively Established Database [O] . Jian-Hua Sun, Zhong-He Ji, Yang Yu, 2016

机译：细胞减灭术加上高温腹腔化疗治疗晚期/复发性上皮性卵巢癌：来自前瞻性数据库的回顾性研究结果

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