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首页> 外文期刊>Food Control >Rapid screening and quantification of cyromazine, melamine, ammelide, ammeline, cyanuric acid, and dicyandiamide in infant formula by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and triple quadrupole mass spectrometry
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Rapid screening and quantification of cyromazine, melamine, ammelide, ammeline, cyanuric acid, and dicyandiamide in infant formula by ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry and triple quadrupole mass spectrometry

机译：超高效液相色谱-四极杆飞行时间质谱法和三重四极杆质谱法快速筛查和定量测定婴儿配方食品中的嘧啶，三聚氰胺，三聚氰胺，氨甲啉，氰尿酸和双氰胺

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摘要

In the past few years, special concern for triazine pesticide cyromazine (CYRO) and its metabolites melamine (MM), ammelide (AMD), ammeline (AMN), cyanuric acid (CA), and dicyandiamide (DCD) residues has arisen in the food safety field on infant foods. In this work, screening and confirmation for infant milk powder samples were performed by quadrupole time-of-flight mass spectrometry (QTOF-MS). An accurate mass database was established. The matrix-matched internal standard calibration curves of UPLC-MS/MS were linear, with correlation coefficient (r(2)) higher than 0.994. The limits of quantification (LOQ) were 1.6, 5.0, 16.5, 10.0, 66.4, and 66.4 mu g/kg for CYRO, MM, AMD, AMN, CA, and DCD, respectively. The average recoveries ranged from 64.8 to 103%. The retention time, intra- and inter-day precisions (relative standard deviation, RSDs) of 6 analytes were in the range of 0.02-0.05%, 2.4 -6.1%, and 7.2-11.2%, respectively. CYRO and MM residues in some infant milk powder samples were confirmed. Quantitation of positive samples was performed using the internal standard method and six-point matrix-matched calibration curves. The content for CYRO in all 8 samples and MM in 4 samples were in the range of 3.5-45 mu g/kg and 8-25 mu g/kg, respectively. The method developed for the first time has high sensitivity, can be used as an effective tool for rapid screening and highly sensitive multiresidue determination of CYRO, MM and their metabolites AMD, AMN, and CA as well as DCD in milk powder samples. (C) 2015 Elsevier Ltd. All rights reserved.
机译：在过去的几年中，食品中出现了对三嗪农药氰嗪（CYRO）及其代谢物三聚氰胺（MM），阿美利特（AMD），氨苯胺（AMN），氰尿酸（CA）和双氰胺（DCD）残留的特殊关注。婴儿食品的安全领域。在这项工作中，通过四极杆飞行时间质谱（QTOF-MS）对婴儿奶粉样品进行了筛选和确认。建立了准确的质量数据库。 UPLC-MS / MS的与基质匹配的内标校准曲线是线性的，相关系数（r（2））高于0.994。 CYRO，MM，AMD，AMN，CA和DCD的定量限（LOQ）分别为1.6、5.0、16.5、10.0、66.4和66.4μg / kg。平均回收率在64.8％至103％之间。 6种分析物的保留时间，日内和日间精度（相对标准偏差，RSD）分别为0.02-0.05％，2.4 -6.1％和7.2-11.2％。确认了一些婴儿奶粉样品中的CYRO和MM残留。使用内标方法和六点矩阵匹配的校准曲线对阳性样品进行定量。所有8个样品中的CYRO含量和4个样品中的MM含量分别在3.5-45μg / kg和8-25μg/ kg范围内。首次开发的方法具有很高的灵敏度，可以用作快速筛查和高灵敏度多残留测定奶粉样品中CYRO，MM及其代谢物AMD，AMN和CA以及DCD的有效工具。 （C）2015 Elsevier Ltd.保留所有权利。

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