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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Shorter CAG repeats in the androgen receptor gene may enhance hyperandrogenicity in polycystic ovary syndrome.
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Shorter CAG repeats in the androgen receptor gene may enhance hyperandrogenicity in polycystic ovary syndrome.

机译：雄激素受体基因中较短的CAG重复可能增强多囊卵巢综合征的雄激素过多性。

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摘要

BACKGROUND: The main goal of the present study was to assess the influence of the androgen receptor gene CAG repeat polymorphism on hyperandrogenism and its phenotypical features in patients with polycystic ovary syndrome (PCOS). METHODS: CAG repeat lengths were analyzed in 97 oligo-anovulatory women with ultrasound features of PCOS. All individuals were assessed for endocrine parameters and their phenotypical features were recorded. These parameters were correlated with the CAG repeat lengths. RESULTS: PCOS patients with a bi-allelic mean lower than 21 repeats had lower dihydrotestosterone levels (p = 0.007), lower androstenedione levels (p = 0.023), lower luteinizing hormone levels (p = 0.023), a lower luteinizing hormone/follicle-stimulating hormone ratio (p = 0.021) and the highest percentage of patients with acne and/or hirsutism (p = 0.021). CONCLUSIONS: Our findings support the hypothesis that the PCOS phenotype may result from either elevated androgen levels or an enhanced sensitivity to androgens caused by a more active androgen receptor.
机译：背景：本研究的主要目的是评估多囊卵巢综合征（PCOS）患者中雄激素受体基因CAG重复多态性对高雄激素血症及其表型特征的影响。方法：分析97例具有PCOS超声特征的无排卵妇女的CAG重复长度。评估所有个体的内分泌参数，并记录其表型特征。这些参数与CAG重复长度相关。结果：双等位基因均值低于21次重复的PCOS患者二氢睾丸激素水平较低（p = 0.007），雄烯二酮水平较低（p = 0.023），黄体生成激素水平较低（p = 0.023），黄体生成激素/卵泡水平较低刺激性激素比（p = 0.021）和痤疮和/或多毛症患者的最高百分比（p = 0.021）。结论：我们的发现支持以下假设：PCOS表型可能是由雄激素水平升高或雄激素受体活性增加引起的对雄激素敏感性增强所致。

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