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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Evaluation of body fat distribution in PCOS and its association with carotid atherosclerosis and insulin resistance
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Evaluation of body fat distribution in PCOS and its association with carotid atherosclerosis and insulin resistance

机译：评估PCOS中人体脂肪分布及其与颈动脉粥样硬化和胰岛素抵抗的关系

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Objective: The aim of this study was to compare body fat distribution in PCOS with healthy controls and to investigate the factors associated with carotid artery intima media thickness (IMT) and insulin resistance. Subjects and Methods: A case control study was conducted in 46 women with PCOS and 43 age matched controls. Anthropometrical measurements, hormonal levels, lipid and glucose profile were evaluated. Body fat thickness in four regions and carotid IMT were measured. Body fat distribution was compared between groups. Correlation of these parameters with carotid artery IMT and insulin resistance was investigated. Result(s): Visceral and subcutaneous fat thickness and the mean carotid artery IMT were significantly higher in PCOS subjects (p<0.01). In correlation analysis, age, body mass index (BMI) and waist hip ratio (WHR) showed correlation with carotid artery IMT (r=0,55, p<0,001; r=0.41, p<0.008 and r=0.34 p=0.03, respectively), whereas visceral fat thickness presented a correlation with HOMA-IR index as a sign of insulin resistance. Conclusion(s): Fat accumulation is more prominent in visceral and subcutaneous regions in PCOS. Increased BMI and abdominal type of obesity are closely related to the increased carotid artery IMT and insulin resistance. Weight control and regional weight loss are important part of the treatment for the future health of women with PCOS.
机译：目的：本研究的目的是比较PCOS与健康对照者体内的脂肪分布，并调查与颈动脉内膜中层厚度（IMT）和胰岛素抵抗相关的因素。受试者与方法：一项病例对照研究在46位PCOS女性患者和43位年龄相匹配的对照人群中进行。人体测量，荷尔蒙水平，脂质和葡萄糖概况进行了评估。测量了四个区域的体脂厚度和颈动脉IMT。比较两组之间的体脂分布。研究了这些参数与颈动脉IMT和胰岛素抵抗的相关性。结果：PCOS受试者的内脏和皮下脂肪厚度以及颈总动脉平均IMT显着更高（p <0.01）。在相关性分析中，年龄，体重指数（BMI）和腰臀比（WHR）与颈动脉IMT相关（r = 0.55，p <0.001; r ​​= 0.41，p <0.008和r = 0.34 p = 0.03 ），而内脏脂肪厚度与HOMA-IR指数呈相关性，表明胰岛素抵抗。结论：PCOS的内脏和皮下区域脂肪积累更为突出。 BMI和腹部肥胖的增加与颈动脉IMT和胰岛素抵抗的增加密切相关。体重控制和区域减肥是PCOS妇女未来健康治疗的重要组成部分。

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