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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Ovulatory effects of flutamide in the polycystic ovary syndrome
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Ovulatory effects of flutamide in the polycystic ovary syndrome

机译：氟他胺对多囊卵巢综合征的排卵作用

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摘要

The long-term effects and tolerability of flutamide (Flu) on the menstrual cycle and the ovulatory function of hyperandrogenic women with or without polycystic ovary syndrome (PCOS) were investigated. The study included 118 white women with the diagnosis of various forms of hyperandrogenism (80 PCOS and 38 non-PCOS patients). Patients received Flu for three years at dosages that declined each of the three years (250, 125 and 62.5mg/day). Sex steroid, ovulatory function and menstrual profile at baseline and during each year of Flu treatment were evaluated. Flu therapy showed a significant increase in the percentage of cycles that were ovulatory (with progesterone concentrations greater than 4ng/ml in mid-luteal phase) and concomitant regularization of the menstrual profile in PCOS patients. A luteinizing hormone decrease and an estrone, estradiol and 17-hydroxyprogesterone increase are also observed during treatment. Regular cycles persisted in non-PCOS patients. The results were maintained during the three years of treatment. The study suggests that Flu is a satisfactory therapeutic regimen of the chronic anovulation and the irregularities of the menstrual cycle in hyperandrogenic PCOS patients in the long run.
机译：研究了氟他胺（Flu）对多囊卵巢综合征（PCOS）与否的高雄激素妇女月经周期和排卵功能的长期影响和耐受性。该研究包括118位诊断出各种形式高雄激素血症的白人妇女（80名PCOS和38名非PCOS患者）。患者接受了三年的流感治疗，剂量每年每三年下降一次（250、125和62.5mg /天）。在基线和每年流感治疗期间评估性激素，排卵功能和月经情况。流感治疗显示排卵周期百分比显着增加（黄体中期黄体酮浓度高于4ng / ml），PCOS患者的月经也随之调整。在治疗期间还观察到促黄体激素减少，雌激素，雌二醇和17-羟孕酮增加。非PCOS患者持续规律的周期。在治疗的三年期间保持了结果。这项研究表明，从长远来看，对于高雄激素性PCOS患者，流感是一种令人满意的慢性无排卵治疗和月经周期不规则的治疗方案。

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