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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >The effects of estrogen and progesterone on blood glutamate levels during normal pregnancy in women
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The effects of estrogen and progesterone on blood glutamate levels during normal pregnancy in women

机译：正常妊娠期间雌激素和孕激素对血谷氨酸水平的影响

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The purpose of this study was to examine whether changes in estrogen and progesterone levels observed during normal pregnancy influence blood glutamate levels. One-hundred and sixteen pregnant women were divided into three groups based on gestational age: group 1 included women in their first trimester, group 2 included women in their second trimester, and group 3 included women in their third trimester. A single venous blood sample was collected and analyzed for concentrations of estrogen, progesterone, glutamate-pyruvate transaminase (GPT), glutamate-oxaloacetate transaminase (GOT), and glutamate. Concentrations of blood glutamate were significantly lower during the second trimester (p<0.001) and third trimester (p<0.001). Blood glutamate levels were inversely correlated with levels of estrogen and progesterone throughout pregnancy (p<0.001). Levels of GOT and GPT remained stable during the course of pregnancy, apart from a moderate reduction in GPT during the third trimester. Increases in estrogen and progesterone levels during advanced stages of pregnancy were inversely correlated with maternal blood glutamate concentrations. Once a maximal blood glutamate-reducing effect was achieved, any additional estrogen and progesterone had a negligible effect on blood glutamate. This study demonstrates the glutamate-reducing effects of estrogen and progesterone, which is most likely not mediated by a GOT/GPT conversion mechanism.
机译：这项研究的目的是检查在正常怀孕期间观察到的雌激素和孕激素水平的变化是否会影响血液谷氨酸水平。根据胎龄，将116名孕妇分为三组：第一组包括孕中期的妇女，第二组包括孕中期的妇女，第三组包括孕晚期的妇女。收集单个静脉血样品并分析雌激素，孕酮，谷氨酸-丙酮酸转氨酶（GPT），谷氨酸-草酰乙酸转氨酶（GOT）和谷氨酸的浓度。在妊娠中期（p <0.001）和妊娠晚期（p <0.001），血液谷氨酸的浓度显着降低。在整个怀孕期间，血液谷氨酸水平与雌激素和孕激素水平呈负相关（p <0.001）。除了妊娠中期的GPT适度降低外，GOT和GPT的水平在妊娠过程中保持稳定。妊娠晚期雌激素和孕激素水平的升高与孕妇血液谷氨酸浓度成反比。一旦达到最大程度的血液谷氨酸减少效果，任何其他雌激素和孕激素对血液谷氨酸的影响可忽略不计。这项研究证明了降低雌激素和孕激素的谷氨酸的作用，这很可能不是由GOT / GPT转换机制介导的。

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