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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >CYP19 gene variants affect the assisted reproduction outcome of women with polycystic ovary syndrome
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CYP19 gene variants affect the assisted reproduction outcome of women with polycystic ovary syndrome

机译：CYP19基因变异影响多囊卵巢综合征女性的辅助生殖结果

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Objective: Cytochrome P450 aromatase catalyzes the irreversible transformation of androgens into estrogens. The association of CYP19(TTTA)n polymorphism with the hormonal profile and the assisted reproduction outcome of women with polycystic ovary syndrome (PCOS) was explored. Methods: One hundred and thirty-two women with PCOS and 200 with male-factor infertility, as controls, participated in the current study. The CYP19(TTTA)n polymorphism was genotyped, while the hormonal profile was determined at the third day of the menstrual cycle. During oocyte retrieval, the follicular size, the follicle and oocyte numbers were recorded. Results: Genotype analysis revealed 6 CYP19(TTTA)n alleles with 7-12 repeats. In PCOS women, the CYP19(TTTA)7 allele presence was associated with lower serum E2 levels at the third day of the menstrual cycle (p<0.009), lower large follicle (p<0.02) and total oocyte numbers (p=0.006), but with significantly higher pregnancy rates after assisted reproduction (p<0.004). Conclusions: Potential associations of the CYP19(TTTA)7 allele with ovarian response to standard gonadotrophin stimulation and with assisted reproduction outcome were found in PCOS women, probably due to androgen/estrogen ratio alterations.
机译：目的：细胞色素P450芳香化酶催化雄激素不可逆转化为雌激素。探讨了CYP19（TTTA）n多态性与女性多囊卵巢综合征（PCOS）的激素水平和辅助生殖结局的关系。方法：以132例女性PCOS患者和200例男性不育患者为对照，参加了本研究。 CYP19（TTTA）n多态性是基因型，而荷尔蒙分布是在月经周期的第三天确定的。在取卵过程中，记录卵泡大小，卵泡和卵母细胞数目。结果：基因型分析显示6个CYP19（TTTA）n等位基因具有7-12个重复序列。在PCOS妇女中，CYP19（TTTA）7等位基因的存在与月经周期第三天血清E2水平降低（p <0.009），大卵泡降低（p <0.02）和总卵母细胞数（p = 0.006）相关，但辅助生殖后的怀孕率明显更高（p <0.004）。结论：在PCOS妇女中发现了CYP19（TTTA）7等位基因与卵巢对标准促性腺激素刺激的反应以及辅助生殖结局之间的潜在联系，这可能是由于雄激素/雌激素比例的改变。

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