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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Hyperuricemia is independently associated with left ventricular hypertrophy in post-menopausal women but not in pre-menopausal women in rural Northeast China
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Hyperuricemia is independently associated with left ventricular hypertrophy in post-menopausal women but not in pre-menopausal women in rural Northeast China

机译：在中国东北农村地区，高尿酸血症与绝经后妇女的左心室肥大独立相关，但与绝经前妇女无关

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The aim of this article is to estimate the relationship between hyperuricemia and left ventricular hypertrophy (LVH) and to investigate whether menopause was associated with the relationship between hyperuricemia and LVH. This survey was conducted from July 2012 to August 2013. A total of 6029 women (3508, 58.2% were post-menopause) from the rural Northeast China were randomly selected and examined. LVH was defined using the 2007 Guidelines for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Age, body mass index, glucose, estimated glomerular filtration rate and lipid level were significantly correlated with serum uric acid level. LVH showed a gradual increase in accordance with the serum uric acid level in entire study population (<4.0 mg/dL, 11.4%; 4 to <5 mg/dL, 14.9%; 5 to <6 mg/dL, 18.9%; >= 6 mg/dL, 27.4%; p < 0.001). Multivariate analysis revealed that hyperuricemia was a significantly independent risk factor for LVH in post-menopausal women [OR (95% CI): 1.367 (1.026, 1.821)], but not in pre-menopausal women [OR (95% CI): 1.290 (0.669, 2.486)]. These findings suggested that hyperuricemia can be used as a risk marker of LVH in a female population and, in particular, as an independent risk factor in post-menopausal women but not in pre-menopausal women.
机译：本文旨在评估高尿酸血症与左心室肥大（LVH）之间的关系，并探讨更年期是否与高尿酸血症与LVH之间的关系有关。该调查于2012年7月至2013年8月进行。从中国东北农村地区随机抽取6029名妇女（3508名，绝经后占58.2％）进行检查。 LVH是根据2007年欧洲高血压学会（ESH）和欧洲心脏病学会（ESC）的动脉高血压管理指南定义的。年龄，体重指数，葡萄糖，估计的肾小球滤过率和脂质水平与血清​​尿酸水平显着相关。 LVH随整个研究人群的血清尿酸水平逐渐升高（<4.0 mg / dL，11.4％; 4至<5 mg / dL，14.9％; 5至<6 mg / dL，18.9％;> = 6 mg / dL，27.4％; p <0.001）。多因素分析显示，高尿酸血症是绝经后妇女LVH的独立危险因素[OR（95％CI）：1.367（1.026，1.821）]，但绝经前妇女则不是[LV（95％CI）：1.290] （0.669，2.486）]。这些发现表明，高尿酸血症可以用作女性人群LVH的危险标志物，尤其是在绝经后妇女而非绝经前妇女中作为独立的危险因素。

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