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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles.
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Assessment of the predictive value of follicular fluid insulin, leptin and adiponectin in assisted reproductive cycles.

机译：评估卵泡液胰岛素，瘦素和脂联素在辅助生殖周期中的预测价值。

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PURPOSE: To assess the correlation of intrafollicular insulin, leptin and adiponectin levels with assisted reproductive technologies (ART) outcome. METHODS: This was a retrospective study of 46 patients undergoing in vitro fertilisation/intracytoplasmic sperm injection. Follicular fluid (FF) samples collected at oocyte retrieval were assayed for insulin, leptin and adiponectin levels using enzyme-linked immunosorbent assay, and correlations with ART outcome were analysed. RESULTS: There was no significant correlation between intrafollicular insulin, leptin and adiponectin levels. There was a significant difference in the concentration of insulin (P = 0.007), but not leptin or adiponectin, between pregnant (n = 20) and non-pregnant (n = 26) cycles. Only two pregnancies was observed in the 12 cycles in which the concentration of insulin was greater than 7 mU/l in FF, while 18 pregnancies was observed in the 34 cycles in which the concentration of insulin was less than 7 mU/l (P = 0.043). The significantly high concentration of insulin in FF was observed in non-pregnant cycles of patients with polycystic ovary syndrome (PCOS). CONCLUSIONS: Our results suggest the possible involvement of intrafollicular insulin in folliculogenesis. Insulin resistance-related substances may affect the reproductive process in patients with PCOS.
机译：目的：评估卵泡内胰岛素，瘦素和脂联素水平与辅助生殖技术（ART）结局的相关性。方法：这是一项回顾性研究，对46例接受体外受精/胞浆内精子注射的患者进行了研究。使用酶联免疫吸附法测定卵母细胞取回时的卵泡液（FF）样品中的胰岛素，瘦素和脂联素水平，并分析其与ART结果的相关性。结果：卵泡内胰岛素，瘦素和脂联素水平之间无显着相关性。在怀孕（n = 20）和未怀孕（n = 26）周期之间，胰岛素浓度存在显着差异（P = 0.007），而瘦蛋白或脂联素则没有差异。在FF中胰岛素浓度大于7 mU / l的12个周期中仅观察到2次怀孕，而在胰岛素浓度小于7 mU / l的34个周期中仅观察到18次怀孕（P = 0.043）。在多囊卵巢综合征（PCOS）患者的非妊娠周期中观察到FF中胰岛素的浓度很高。结论：我们的结果提示卵泡内胰岛素可能参与卵泡形成。胰岛素抵抗相关物质可能会影响PCOS患者的生殖过程。

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