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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Increasing hirsutism due to a granulosa-cell tumor in a woman with polycystic ovary syndrome: case report and review of the literature
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Increasing hirsutism due to a granulosa-cell tumor in a woman with polycystic ovary syndrome: case report and review of the literature

机译：多囊卵巢综合征女性由于颗粒细胞瘤引起的多毛症：病例报告和文献复习

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Background: Granulosa-cell tumors (GCT), rare malignancies that arise from sex-cord stromal cells, account for less than 5% of ovarian tumors. These tumors present with an endocrine syndrome and mass signs. Surgery is the primary treatment approach. The risk of recurrence is more frequent in the juvenile-onset form.Case report: We report the case of an obese 18-year-old Caucasian women with hirsutism and oligomenorrhea. Abdominal palpation revealed a voluminous firm mass. Hormonal evaluation documented severe hyperandrogenism. The ovary-specific tumor marker CA125 was elevated, whereas human-chorionic-gonadotropin was in the normal range. Abdominal imaging examination revealed a 19 cm mass in the left ovary. Twenty-four hours after removal of the mass, menstrual flow reappeared and androgens progressively normalized. Microscopically, the predominant pattern was one of uniform, bland, epithelioid to spindle-shaped cells. After three months, a significant weight loss was recorded, hirsutism had decreased slightly and oligomenorrhea reappeared. A4-Androstenedione levels remained elevated (4200 ng/L), whereas CA125 had normalized. In light of the pre-existing polycystic-ovary-syndrome (PCOS), the patient started estrogen-progestin treatment.Conclusion: We report an interesting case of a woman with severe hirsutism due to GCT, and a history of oligomenorrhea caused by PCOS. After surgery, a dramatic clinical improvement was observed, whereas PCOS signs persisted.
机译：背景：颗粒性间质细胞引起的罕见恶性肿瘤是颗粒细胞瘤（GCT），仅占卵巢肿瘤的不到5％。这些肿瘤表现为内分泌综合征和肿块。手术是主要的治疗方法。少年发病形式的复发风险更高。病例报告：我们报道了一名肥胖的18岁白人妇女，患有多毛症和少经症。腹部触诊可见大量硬块。激素评估表明严重的高雄激素血症。卵巢特异性肿瘤标志物CA125升高，而人绒毛膜促性腺激素在正常范围内。腹部影像学检查发现左卵巢有19 cm肿块。去除肿块后二十四小时，月经重新出现，雄激素逐渐恢复正常。在显微镜下，主要模式是均匀，平淡，上皮样到纺锤形细胞之一。三个月后，记录到体重明显减轻，多毛症略有减少，并再次出现了月经。 A4-雄烯二酮水平仍然升高（4200 ng / L），而CA125已恢复正常。鉴于先前存在的多囊卵巢综合症（PCOS），患者开始进行雌激素-孕激素治疗。结论：我们报道了一个有趣的病例，该妇女因GCT严重患有多毛症，并有因PCOS引起的少经的病史。手术后，观察到巨大的临床改善，而PCOS体征持续存在。

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