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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Term pregnancy and live birth subsequent to immediate uterine transfer of sperm microinjected oocyte in a natural cycle
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Term pregnancy and live birth subsequent to immediate uterine transfer of sperm microinjected oocyte in a natural cycle

机译:精子显微注射卵母细胞在自然周期中立即子宫转移后的足月妊娠和活产

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摘要

It has been reported that it is possible to achieve a pregnancy after immediate uterine transfer of oocyte and sperm, before fertilization and cleavage were known to have occurred; there is an enormous amount of work about the optimal timing of embryo transfer, with no conclusive evidence of a gold standard satisfying patient age, endometrial receptivity, hormonal levels and embryological parameters. We hereby report a case of one 35-year-old nulligravid woman with longstanding tubal factor infertility and 3 previous failed ICSI cycles, treated with ICSI and immediate transfer of the oocyte microinjected with a spermatozoon in a natural cycle. A single oocyte was retrieved, injected with a spermatozoon and transferred 40 min after injection, resulting in an uneventful pregnancy and delivery of a healthy female infant weighing 3320 g at 40 weeks' estimated gestational age. This case, certainly novel, should be interpreted with caution. Whether confirmed for efficacy and safeness in appropriate controlled clinical trials, our present observation could offer a simple, practical and cost-effective approach in ART programs in selected patients.
机译:据报道,在卵子和精子立即子宫转移后,在已知发生受精和卵裂之前,有可能怀孕。关于胚胎移植的最佳时机,还有大量工作要做,没有确凿的证据表明金标准可以满足患者的年龄,子宫内膜的接受性,激素水平和胚胎学参数。我们在此报告一例35岁的无效孕妇,该患者长期存在输卵管因素不孕症,并且之前有3个失败的ICSI周期,接受ICSI治疗,并在自然周期中立即注射了显微注射精子的卵母细胞。取回一个卵母细胞,注射精子并在注射后40分钟转移,导致妊娠顺利进行,并在40周的估计胎龄时分娩体重为3320 g的健康女婴。这种情况,当然是新颖的,应谨慎解释。无论是否在适当的对照临床试验中证实了疗效和安全性,我们目前的观察结果都可以为某些患者的ART计划提供一种简单,实用和具有成本效益的方法。

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