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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Effects of triploidy incidence on clinical outcomes for IVF-ET cycles in different ovarian stimulation protocols
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Effects of triploidy incidence on clinical outcomes for IVF-ET cycles in different ovarian stimulation protocols

机译：三倍体发生率对不同卵巢刺激方案中IVF-ET周期临床结果的影响

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Purpose: To discuss the relationship between triploidy incidence and clinical outcomes of embryos derived from normally fertilized oocytes from the same cohort for in vitro fertilization-embryo transfer (IVF-ET) cycles in different ovarian stimulation protocol.Methods: This study included 2070 in vitro fertilization (IVF) cycles with long-term protocol, 802 IVF cycles with ultra short-term protocol and 508 IVF-D (in vitro fertilization by donor semen) cycles with long-term protocol from January 2013 to September 2014. According to the different 3PN rate, patients were divided into three groups as follows: Group 1 included patients with 0% 3PN zygotes, Group 2 included patients with 1-25% 3PN zygotes and Group 3 included patients with >25% 3PN zygotes. Main outcome measure: female age, no. of retrieved oocytes, normal fertilization rate, day-3 grade I+II embryos rate, day-3 grade I+II+III embryos rate, implantation rate, pregnancy rate and early abortion rate.Results: Triploidy cycle incidence rate in IVF and IVF-D cycles with long-term protocol were significantly higher than in IVF cycles with ultra short-term protocol (p<0.001). Triploidy fertilization rate found no significant difference between the three groups (p>0.05). In three protocols, normal fertilization rate in 3PN=0% and 3PN=1-25% groups were significantly higher compared to 3PN>25% group (p<0.001). In IVF cycles with long-term protocol, the day-3 grade I+II embryos, implantation and pregnancy rate in 3PN>25% group were significantly lower than other two groups (p<0.05). The day-3 grade I+II+III embryos and early abortion rate found no significant difference between the three groups (p>0.05). In IVF cycles with ultra short-term protocol, there were no significant differences found in day-3 grade I+II embryos, day-3 grade I+II+III embryos, implantation, pregnancy and early abortion rate (p>0.05). In IVF-D cycles with long-term protocol, the day-3 grade I+II embryos, day-3 grade I+II+III embryos and implantation rate in 3PN>25% group were significantly lower than other two groups (p<0.05). The pregnancy and early abortion rates found no significant difference in the three groups (p>0.05).Conclusion: We observed that high proportion of triploid zygotes made a negative effect on clinical outcomes for IVF-ET cycles with long-term protocol.
机译：目的：探讨三倍体发生率与同一个队列的正常受精卵子在不同卵巢刺激方案中的体外受精-胚胎移植（IVF-ET）周期的胚胎的临床结局之间的关系。方法：本研究包括2070个体外2013年1月至2014年9月，采用长期方案的受精（IVF）周期，采用超短期方案的802 IVF周期和采用长期方案的508 IVF-D（供体精液的体外受精）周期。 3PN发生率，将患者分为三组：第1组包括0％3PN受精卵的患者，第2组包括1-25％3PN受精卵的患者，第3组包括> 25％3PN受精卵的患者。主要结果指标：女性年龄，否。卵母细胞的回收率，正常受精率，第3天I + II级胚胎率，第3天I + II + III级胚胎率，着床率，妊娠率和早期流产率。结果：IVF和IVF的三倍体周期发生率长期方案的-D周期显着高于超短期方案的IVF周期（p <0.001）。三倍体受精率在三组之间没有显着差异（p> 0.05）。在三种方案中，3PN = 0％和3PN = 1-25％组的正常受精率显着高于3PN> 25％组（p <0.001）。在具有长期方案的IVF周期中，3PN> 25％组的第3天I + II级胚胎，着床和妊娠率显着低于其他两组（p <0.05）。三组I + II + III级第3天胚胎和早期流产率之间无显着差异（p> 0.05）。在采用超短期方案的IVF周期中，第3天I + II级胚胎，第3天I + II + III级胚胎，着床，妊娠和早期流产率没有显着差异（p> 0.05）。在长期试验的IVF-D周期中，3PN> 25％组的第3天I + II胚胎，第3天I + II + III胚胎和着床率明显低于其他两组（p < 0.05）。三组的妊娠率和早期流产率无显着性差异（p> 0.05）。结论：我们观察到三倍体合子的高比例对长期方案的IVF-ET周期的临床结局产生负面影响。

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