What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma.

Lana MB; Straminsky V; Onetto C; Amuchastegui JM; Blanco G; Galluzzo L; Provenzano S; Nolting M

首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma.

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What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma.

机译：自发性卵巢早衰导致骨质流失的真正原因是什么？一个新的谜团。

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OBJECTIVE: To determine if there is a relation between the follicle-stimulating hormone (FSH) and oestradiol levels with values found in bone mineral density, at lumbar spinal and femoral neck levels, in patients with spontaneous premature ovarian failure (POF) as at the time of diagnosis. METHOD: Cross-sectional study. Eighty-five patients were selected with a diagnosis of POF. Inclusion criteria. Forty women with bone mineral density (BMD) in any of the regions, that is, lumbar spine column or femoral neck. Forty-two age-matched healthy women were included as controls. RESULTS: The average FSH value found was 80.11 mUI/ml, while the oestradiol average value was 37.2 pg/ml. The FSH values were correlated with the BMD values at the lumbar spinal column (p < 0.002) and the femoral neck (p < 0.002). The oestradiol values did not bear any relation with the BMD values in L2-L4 (p = 0.420) nor with the femoral neck (p = 0.868). CONCLUSIONS: High FSH concentrations, but not oestradiol, are positively associated with bone mass loss in both skeletal regions, in patients with spontaneous POF.

机译：目的：确定自发性卵巢早衰（POF）患者的卵泡刺激素（FSH）和雌二醇水平与腰椎和股骨颈水平的骨矿物质密度值之间是否存在相关性。诊断时间。方法：横断面研究。选择八十五名诊断为POF的患者。纳入标准。在任何区域，即腰椎柱或股骨颈中有40名女性的骨矿物质密度（BMD）。包括四十二名年龄匹配的健康妇女作为对照。结果：测得的平均FSH值为80.11 mUI / ml，而雌二醇的平均值为37.2 pg / ml。 FSH值与腰椎柱（p <0.002）和股骨颈（p <0.002）的BMD值相关。雌二醇值与L2-L4中的BMD值（p = 0.420）和股骨颈（p = 0.868）没有任何关系。结论：自发性POF患者中，高FSH浓度而不是雌二醇与骨质损失呈正相关。

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《Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology》 |2010年第10期|共5页
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Lana MB; Straminsky V; Onetto C; Amuchastegui JM; Blanco G; Galluzzo L; Provenzano S; Nolting M;
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中图分类妇产科学;内分泌腺疾病及代谢病;
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1. What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma. [J] . Lana MB, Straminsky V, Onetto C, Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology . 2010,第10期

机译：自发性卵巢早衰导致骨质流失的真正原因是什么？一个新的谜团。
2. Factors associated with bone density in young women with karyotypically normal spontaneous premature ovarian failure. [J] . Leite Silva P, Bedone A, Pinto Neto AM, Archives of gynecology and obstetrics. . 2009,第2期

机译：与核型正常的自发性卵巢早衰的年轻女性的骨密度相关的因素。
3. Factors associated with bone density in young women with karyotypically normal spontaneous premature ovarian failure [J] . Paula Leite-Silva, Aloísio Bedone, Aarão Mendes Pinto-Neto, Archives of Gynecology and Obstetrics . 2009,第2期

机译：核型正常自发性卵巢早衰的年轻女性的骨密度相关因素
4. Premature Ovarian Failure and Decline of Ovarian Reserve Function [C] . Xiaojun Liu, Lingling Tong International Conference on Biomedical Sciences and Information Systems;Hebei University of Science and Technology . 2019

机译：卵巢早衰和卵巢储备功能下降
5. Long-Term Bone Mineral Density Loss Following Autologous and Allogeneic Hematopoietic Cell Transplantation and Effectiveness of Bone Loss Therapies to Combat the Loss. [D] . Croudy, Christopher M. 2012

机译：自体和同种异体造血细胞移植后的长期骨矿物质密度损失以及抗击骨损失疗法的有效性。
6. A case report of spontaneous pregnancy during hormonal replacement therapy for premature ovarian failure [O] . Firoozeh Akbari Asbagh, Mahbod Ebrahimi 2011

机译：激素替代治疗卵巢早衰患者自发妊娠的一例报告
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What is really responsible for bone loss in spontaneous premature ovarian failure? A new enigma.

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