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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Polymorphism of MDM2 promoter 309 (rs 2279744) and the risk of PCOS
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Polymorphism of MDM2 promoter 309 (rs 2279744) and the risk of PCOS

机译：MDM2启动子309（rs 2279744）的多态性和PCOS的风险

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摘要

This study aimed at evaluating possible association between MDM2 SNP309 polymorphism (rs 2279744) and polycystic ovary syndrome (PCOS). One hundred and twenty-five women with PCOS and two hundred and fifty women without PCOS were collected from the department of reproductive medicine of college hospital in this case-control study. Peripheral blood samples were collected from all participants and DNA was extracted, MDM2 SNP309 polymorphism (rs 2279744) was determined from the 125 cases and 250 controls. Women were grouped into PCOS (n = 125) group and control group (n = 250). Odds ratios (OR) and 95% confidence intervals (CI) were used to evaluate the association between MDM2 SNP309 polymorphism (rs 2279744) and PCOS. The distribution of T allele was significant higher in PCOS cases than controls. MDM2 SNP 309 T allele is associated with PCOS.
机译：这项研究旨在评估MDM2 SNP309多态性（rs 2279744）与多囊卵巢综合征（PCOS）之间的可能关联。在该病例对照研究中，从大学医院生殖医学科收集了125名患有PCOS的妇女和250名没有PCOS的妇女。收集所有参与者的外周血样本并提取DNA，从125例病例和250例对照中确定MDM2 SNP309多态性（rs 2279744）。将女性分为PCOS组（n = 125）和对照组（n = 250）。奇数比（OR）和95％置信区间（CI）用于评估MDM2 SNP309多态性（rs 2279744）与PCOS之间的关联。在PCOS病例中，T等位基因的分布明显高于对照。 MDM2 SNP 309 T等位基因与PCOS相关。

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