...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Gynecologie, obstetrique & fertilit >Vitrification: a future technique for ovarian cryopreservation? Physical basis of cryobiology, advantages and limits
【24h】

Vitrification: a future technique for ovarian cryopreservation? Physical basis of cryobiology, advantages and limits

机译：玻璃化：卵巢冷冻保存的未来技术？冷冻生物学的物理基础，优点和局限性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Ovarian cryopreservation is presently indicated in patients who undergo a gonadotoxic treatment, most commonly for anticancer procedures. These procedures can strongly alter fertility by damaging the follicular ovarian reserve. Although six human live births have been described in the world after ovarian tissue cryopreservation and autografting, the techniques of cryopreservation techniques are not consensual. Vitrification is a physical process that allows cryopreservation without formation of ice crystals, by transformation of a highly concentrated solution in a glassy or amorphous state. Vitrification is at present rapidly expanding in the biology of reproduction. With the classic methods of freezing, formation of ice crystals within the ovarian tissue is systematic and can entail cellular lesions. Which is why more and more teams question the theoretical advantage of the vitrification for ovarian cryopreservation. Our objective was to summarize the fundamental physical basis of cryobiology, necessary for an understanding of vitrification. From our experience, we also wanted to point out the practical difficulties of this technique, and we are proposing a model of evaluation and validation that uses differential scanning calorimetry, applicable to any protocol of vitrification.
机译：目前，在接受性腺毒性治疗的患者中最常使用卵巢冷冻保存，通常用于抗癌手术。这些程序可以通过破坏卵泡卵巢储备来强烈改变生育能力。尽管在卵巢组织冷冻保存和自体移植后，世界上已有6个人活产，但冷冻保存技术尚无共识。玻璃化是一种物理过程，通过将高度浓缩的溶液转变为玻璃态或非晶态，可以冷冻保存而不会形成冰晶。目前，玻璃化在生殖生物学中正在迅速扩展。使用经典的冷冻方法，卵巢组织内冰晶的形成是系统性的，并可能引起细胞病变。这就是为什么越来越多的团队质疑玻璃化对卵巢冷冻保存的理论优势的原因。我们的目标是总结冷冻生物学的基本物理基础，这对于理解玻璃化是必不可少的。根据我们的经验，我们还想指出该技术的实际困难，并且我们提出了一种使用差示扫描量热法的评估和验证模型，该模型适用于任何玻璃化方案。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号