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首页> 外文期刊>Gynecologie, obstetrique & fertilit >Efficiency of antagonist IVF cycle programming by estrogens
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Efficiency of antagonist IVF cycle programming by estrogens

机译：雌激素拮抗剂IVF周期编程的效率

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OBJECTIVE: Assess the efficiency of estradiol programming in In Vitro Fertilization (IVF) with antagonists by comparing with classical long luteal agonist protocol. PATIENTS AND METHODS: It is a prospective randomized study, comparing 426 cycles in the arm estradiol antagonist with 412 cycles in the arm long agonist. Estradiol 4 mg/day begins on the 25th day of the previous cycle and continues during the menses until the first day of the stimulation which is from Thursday to Sunday whatever the beginning of the menses. The luteal protocol use Decapeptyl 0,1mg which begins on the 20th day of the previous cycle. RESULTS: Our two populations are similar. No pick-up has been done on Sunday. We have got significantly less oocytes and embryos in estradiol-antagonist (6,8+/-5,3 vs 7,6+/-5,7) and (3,7+/-3,2 vs 4,1+/-3,6) respectively. The ongoing pregnancy rate is comparable in the two groups: 28,6 % for estradiol antagonist 27,9 % for agonist for the whole population and 37 % vs 34,8 % respectively when at least one top embryo was transferred. DISCUSSION AND CONCLUSION: Programming antagonist cycles with estradiol allows the organization of the center; it is easy to implement and seems to give results as good as a long agonist protocol.
机译：目的：与传统的长黄体激动剂方案比较，评估拮抗剂在体外受精中雌二醇编程的效率。患者与方法：这是一项前瞻性随机研究，比较了手臂雌二醇拮抗剂中的426个周期与手臂长激动剂中的412个周期。雌二醇4毫克/天从上一周期的第25天开始，并且在月经期间一直持续到刺激的第一天，无论月经开始于什么，刺激的日期都是从周四到周日。黄体治疗方案使用0.1mg Decapeptyl，起始剂量为前一个周期的第20天。结果：我们的两个人口相似。周日没有接机。雌二醇拮抗剂的卵母细胞和胚胎数量明显减少（6,8 +/- 5,3 vs 7,6 +/- 5,7）和（3,7 +/- 3,2 vs 4,1 + / -3,6）。两组的持续妊娠率相当：雌二醇拮抗剂的总妊娠率为28.6％，激动剂的总妊娠率为29.9％，而至少移植了一个顶级胚胎的妊娠率分别为37％和34.8％。讨论与结论：用雌二醇编程拮抗药周期可以使中心组织起来。它很容易实现，而且效果与长效激动剂协议一样好。

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