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首页> 外文期刊>Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology >Dydrogesterone use in early pregnancy
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Dydrogesterone use in early pregnancy

机译：孕早期使用去氢孕酮

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摘要

Successful oocyte implantation and a favorable pregnancy outcome rely on optimal progesterone levels. Therefore, progesterone deficiencies associated with infertility and miscarriage have commonly been treated with progestogens that mimic the activity of progesterone. Among those is dydrogesterone, an oral retrosteroid with a structure closely related to that of progesterone yet with a greater bioavailability and higher selectivity for the progesterone receptor. This review describes the efficacy of dydrogesterone for the treatment of threatened and recurrent miscarriage, and infertility due to luteal phase insufficiency. Data from clinical trials evaluating dydrogesterone in assisted reproductive technology are also discussed. Prospective clinical trials, systematic reviews and meta-analyses have demonstrated that dydrogesterone significantly improves pregnancy outcomes in women with threatened miscarriage or with a history of miscarriage. Although this is not yet a registered indication, dydrogesterone was as effective as vaginal micronized progesterone for luteal phase support in the setting of assisted reproductive technology. The safety and tolerability of dydrogesterone treatment in pregnant women are also briefly addressed and the data support a well-established and favorable benefit-risk profile.
机译：成功的卵母细胞植入和良好的妊娠结局取决于最佳的孕激素水平。因此，通常用模仿孕酮活性的孕激素治疗与不育和流产有关的孕酮缺乏症。其中有dydrogesterone，一种口服逆转录类固醇，其结构与孕激素紧密相关，但具有更高的生物利用度和对孕激素受体的更高选择性。这篇综述描述了dydrogesterone治疗先兆性和反复性流产以及由于黄体期功能不全引起的不育的功效。还讨论了在辅助生殖技术中评估dydrogesterone的临床试验数据。前瞻性临床试验，系统评价和荟萃分析表明，孕激素会流产或有流产史的女性，dydrogesterone可以显着改善妊娠结局。尽管这还不是注册的适应症，但在辅助生殖技术的背景下，dydrogesterone与黄体酮的阴道微粒化孕酮一样有效。还简要介绍了孕酮治疗的安全性和耐受性，这些数据支持了建立良好的有利风险曲线。

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