Don't forget fallopian tubes! A morphologic and immunohistochemical study about Fallopian tubes with genetic risk (BRCA mutation) [N'oubliez pas les trompes ! étude morphologique et immunohistochimique des trompes à risque génétique (mutation BRCA)]

ChêneG.; RaoelfilsI.; CayreA.; DauplatJ.; BignonY.-J.; JaffeuxP.; Aublet-CuvelierB.; Penault-LlorcaF.

首页> 外文期刊>Gynecologie, obstetrique & fertilit >Don't forget fallopian tubes! A morphologic and immunohistochemical study about Fallopian tubes with genetic risk (BRCA mutation) [N'oubliez pas les trompes ! étude morphologique et immunohistochimique des trompes à risque génétique (mutation BRCA)]

【24h】

Don't forget fallopian tubes! A morphologic and immunohistochemical study about Fallopian tubes with genetic risk (BRCA mutation) [N'oubliez pas les trompes ! étude morphologique et immunohistochimique des trompes à risque génétique (mutation BRCA)]

机译：不要忘记输卵管！有关具有遗传风险（BRCA突变）的输卵管的形态学和免疫组化研究[不要忘记这些管！有遗传风险（BRCA突变）的试管的形态学和免疫组化研究]

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Objectives: The objective of this study was to describe morphologic and immunohistochemical features of precursor tubal lesions in prophylactically removed Fallopian tubes. Patients and methods: Hundred and forty-seven bilateral salpingectomies (genetic predisposition or group A: n=57; and control group or group B: n=90) were reviewed by two pathologists blinded to clinical data. Seven epithelial cytological and architectural features were studied to compare the degree of tubal epithelial abnormalities between the two groups. Immunohistochemical expression patterns of Ki67 and p53 were also evaluated. Results: Serous tubal intraepithelial lesions (STIL) have been identified in group A with stronger expression for Ki67 and p53 (especially in BRCA 1 group) than in group B. Discussion and conclusion: The current results show the importance of salpingo-oophrectomy in BRCA mutation carriers and the complete histopathological sampling of the Fallopian tubes.

机译：目的：本研究的目的是描述预防性切除输卵管中前体输卵管病变的形态和免疫组化特征。患者和方法：由两名对临床数据不了解的病理学家对一百四十七例双侧输卵管切除术（遗传易感性或A组：n = 57;对照组或B组：n = 90）进行了检查。研究了七个上皮细胞学和结构特征，以比较两组之间的输卵管上皮异常程度。还评估了Ki67和p53的免疫组织化学表达模式。结果：在A组中已鉴定出浆液性输卵管上皮内病变（STIL），其Ki67和p53的表达（特别是在BRCA 1组中）比在B组中强。讨论和结论：当前结果表明输卵管上皮切除术在BRCA中的重要性突变携带者和输卵管的完整组织病理学采样。

著录项

来源
《Gynecologie, obstetrique & fertilit》 |2012年第1期|共5页
作者
ChêneG.; RaoelfilsI.; CayreA.; DauplatJ.; BignonY.-J.; JaffeuxP.; Aublet-CuvelierB.; Penault-LlorcaF.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 fre
中图分类妇产科学;
关键词
BRCA; Fallopian tube neoplasms; Ovarian cancer; p53; Prophylactic salpingo-oophorectomy;

机译：BRCA;输卵管肿瘤;卵巢癌;p53;预防性输卵管卵巢切除术;

相似文献

外文文献
中文文献
专利

1. Don't forget fallopian tubes! A morphologic and immunohistochemical study about Fallopian tubes with genetic risk (BRCA mutation) [N'oubliez pas les trompes ! étude morphologique et immunohistochimique des trompes à risque génétique (mutation BRCA)] [J] . ChêneG., RaoelfilsI., CayreA., Gynecologie, obstetrique & fertilit . 2012,第1期

机译：不要忘记输卵管！有关具有遗传风险（BRCA突变）的输卵管的形态学和免疫组化研究[不要忘记这些管！有遗传风险（BRCA突变）的试管的形态学和免疫组化研究]
2. Incidence of Hypersensitivity Reactions to Carboplatin or Paclitaxel in Patients With Ovarian, Fallopian Tube, or Primary Peritoneal Cancer With or Without BRCA1 or BRCA2 Mutations [J] . ANDREW GARCIA, COREY FRAHM, JOANNE M. JETER, Journal of the advanced practitioner in oncology . 2019,第5期

机译：在卵巢，输卵管管或原发性腹膜癌患者中对卡铂或紫杉醇的过敏反应发生率，或没有BRCA1或BRCA2突变
3. The impact of tissue block sampling on the detection of p53 signatures in fallopian tubes from women with BRCA 1 or 2 mutations (BRCA|[plus]|) and controls [J] . Karishma K Mehra, Martin C Chang, Ann K Folkins, Modern Pathology . 2011,第1期

机译：组织块取样对患有BRCA 1或2突变（BRCA | + |）和对照的女性输卵管中p53信号的检测的影响
4. A phase II evaluation of the potent highly selective PARP inhibitor veliparib in the treatment of persistent or recurrent epithelial ovarian fallopian tube or primary peritoneal cancer in patients who carry a germline BRCA1 or BRCA2 mutation – an NRG Oncology/Gynecologic Oncology Group study [O] . Robert L. Coleman, Michael W. Sill, Katherine Bell-McGuinn, -1

机译：NRG肿瘤/妇科肿瘤小组研究对强效高度选择性的PARP抑制剂veliparib在患有生殖系BRCA1或BRCA2突变的患者中持续或复发的上皮性卵巢癌输卵管或原发性腹膜癌的II期评估
5. Comparison of Hypersensitivity Reaction Incidence to Carboplatin in Patients with Ovarian, Fallopian Tube, or Primary Peritoneal Cancer with or without the BRCA1 or BRCA2 Mutations [O] . Garcia Andrew, Corey Frahm 2017

机译：具有或不具有BRCA1或BRCA2突变的卵巢癌，输卵管癌或原发性腹膜癌患者对卡铂的超敏反应发生率的比较

Don't forget fallopian tubes! A morphologic and immunohistochemical study about Fallopian tubes with genetic risk (BRCA mutation) [N'oubliez pas les trompes ! étude morphologique et immunohistochimique des trompes à risque génétique (mutation BRCA)]

摘要

著录项

相似文献

相关主题

期刊订阅