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首页> 外文期刊>Forensic science international >Determination of illicit drugs in seized materials: role of sampling and analysis in estimation of measurement uncertainty.
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Determination of illicit drugs in seized materials: role of sampling and analysis in estimation of measurement uncertainty.

机译：缉获材料中非法药物的确定：抽样和分析在估计测量不确定度中的作用。

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摘要

The determination of illicit active ingredients in seized materials, in order to assess penal or administrative offences, is routinely carried out in many forensic toxicology laboratories. This paper presents main features of the protocol adopted in the Authors' laboratory for the above investigations. In particular, sampling and analysis are considered as the same measurement process quantifying their combined contribution to overall measurement uncertainty. Aspects concerning representative sampling in the case of single and multiple items are discussed. The effects of material heterogeneity are considered by analyzing separately distinct primary samples taken from different parts of the sampling target. Possible errors due to particles dimension that could arise when sub-sampling are also considered. Analytical precision, bias and other matrix effects are studied in order to quantify the component of the overall measurement uncertainty associated to the analysis of prepared test samples. Typical scenarios arising when measurement results are used to assess compliance with specification limits are also discussed revealing the crucial role of measurement uncertainty.
机译：为了评估刑事或行政犯罪，通常在许多法医毒理学实验室中进行缉获材料中非法活性成分的测定。本文介绍了作者实验室在上述研究中采用的协议的主要功能。尤其是，采样和分析被视为同一测量过程，量化了它们对整体测量不确定性的综合贡献。讨论了有关单个项目或多个项目下代表性抽样的各个方面。通过分别分析从采样目标不同部分获取的不同原始样本，来考虑材料异质性的影响。还考虑了由于子尺寸而导致的可能误差，这些误差可能会在二次采样时出现。研究分析精度，偏差和其他基质效应，以便量化与准备的测试样品的分析相关的整体测量不确定度的组成部分。还讨论了使用测量结果评估是否符合规格限制时出现的典型情况，从而揭示了测量不确定性的关键作用。

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