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Pulmonary innate lymphoid cells regulate repair and remodeling after acute lung injury.

机译:肺先天性淋巴样细胞可调节急性肺损伤后的修复和重塑。

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摘要

The restoration of lung-tissue architecture and a return to a homeostatic state following injury or inflammation is critical to effective pulmonary function. This article assesses the findings of a recently published study by Monticelli et al. in Nature Immunology that describes a novel population of innate lymphoid cells in the lungs of mice and humans, with a critical role in restoring epithelial airway integrity following influenza infection. The significance of this study in the context of our current knowledge of innate lymphoid cells, and its implications and potential for therapeutic manipulation, shall be evaluated within this article.
机译:肺组织结构的恢复以及受伤或发炎后恢复体内稳态对于有效的肺功能至关重要。本文评估了Monticelli等人最近发表的一项研究的发现。在《自然免疫学》(Nature Immunology)中描述了一种新的小鼠和人类肺部先天淋巴样细胞种群,在流感感染后恢复上皮气道完整性方面起着至关重要的作用。在我们目前对先天淋巴样细胞的了解的背景下,这项研究的意义及其在治疗中的意义和潜力应在本文中进行评估。

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