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Treatment and prevention of malaria in pregnancy: opportunities and challenges.

机译：孕妇疟疾的治疗和预防：机遇与挑战。

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摘要

Control of malaria in pregnancy through prevention or treatment may save lives of mothers and babies. Selection of drugs for treatment of infected pregnant women, or for prevention in exposed populations is problematic owing to resistance to established drugs and lack of pregnancy-specific safety and pharmacological data for new drugs. Encouragingly, a number of new drugs and combinations of drugs hold promise for effective treatment, but adequate data on their safety in pregnancy is currently lacking. Our principal challenges are to decide which drugs to develop for use in malaria treatment and prevention in pregnancy and to develop mechanisms to rapidly and comprehensively evaluate their safety. Prevention of pregnancy malaria by vaccination may also become possible, but targets must be closely defined, and strategies developed to test candidates against meaningful end points.
机译：通过预防或治疗控制怀孕期间的疟疾可以挽救母亲和婴儿的生命。由于对既定药物的耐药性以及缺乏针对新药物的特定于妊娠的安全性和药理学数据，因此选择用于治疗感染孕妇或在暴露人群中预防的药物是有问题的。令人鼓舞的是，许多新药和药物组合有望有效治疗，但目前缺乏有关其在妊娠中安全性的足够数据。我们面临的主要挑战是，确定要开发用于妊娠疟疾治疗和预防的药物，并开发机制以快速全面地评估其安全性。通过疫苗预防孕妇疟疾也可能成为可能，但必须严格定义目标，并制定策略以针对有意义的终点测试候选人。

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