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首页> 外文期刊>Forensic science, medicine, and pathology >The presence of enterovirus, adenovirus, and parvovirus B19 in myocardial tissue samples from autopsies: An evaluation of their frequencies in deceased individuals with myocarditis and in non-inflamed control hearts
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The presence of enterovirus, adenovirus, and parvovirus B19 in myocardial tissue samples from autopsies: An evaluation of their frequencies in deceased individuals with myocarditis and in non-inflamed control hearts

机译：尸检的心肌组织样品中存在肠道病毒，腺病毒和细小病毒B19：评估死者患有心肌炎的个体和未发炎的对照心脏中它们的频率

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Purpose: Multiple viruses have been detected in cardiac tissue, but their role in causing myocarditis remains controversial. Viral diagnostics are increasingly used in forensic medicine, but the interpretation of the results can sometimes be challenging. In this study, we examined the prevalence of adenovirus, enterovirus, and parvovirus B19 (PVB) in myocardial autopsy samples from myocarditis related deaths and in non-inflamed control hearts in an effort to clarify their significance as the causes of myocarditis in a forensic material. Methods: We collected all autopsy cases diagnosed with myocarditis from 1992 to 2010. Eighty-four suicidal deaths with morphologically normal hearts served as controls. Polymerase chain reaction was used for the detection of the viral genomes (adenovirus, enterovirus, and PVB) in myocardial tissue specimens. The distinction between acute and persistent PVB infection was made by the serological determination of PVB-specific immunoglobulins M and G. Results: PVB was detected in 33 of 112 (29 %) myocarditis cases and 37 of 84 (44 %) control cases. All of the samples were negative for the presence of adenovirus and enterovirus. Serological evidence of an acute PVB infection, determined by the presence of immunoglobulin M, was only present in one case. In the remaining cases, PVB was considered to be a bystander with no or limited association to myocardial inflammation. Conclusion: In this study, adenovirus, enterovirus, and PVB were found to be rare causes of myocarditis. The detection of PVB in myocardial autopsy samples most likely represents a persistent infection with no or limited association with myocardial inflammation. The forensic investigation of myocardial inflammation demands a thorough examination, including special attention to non-viral causes and requires a multidisciplinary approach.
机译：目的：在心脏组织中已检测到多种病毒，但它们在引起心肌炎中的作用仍存在争议。病毒诊断法医越来越多地使用，但是结果的解释有时可能具有挑战性。在这项研究中，我们检查了心肌炎相关死亡和非发炎对照心脏的心肌解剖样本中腺病毒，肠病毒和细小病毒B19（PVB）的流行，以阐明其作为法医材料中心肌炎原因的重要性。方法：我们收集了1992年至2010年间所有诊断为心肌炎的尸检病例。以84例形态正常的自杀死亡病例作为对照。聚合酶链反应用于检测心肌组织标本中的病毒基因组（腺病毒，肠病毒和PVB）。通过血清学测定PVB特异性免疫球蛋白M和G来区分急性和持续性PVB感染。结果：在112例心肌炎病例中，有33例（29％）和84例对照病例中有37例（44％）检出了PVB。所有样品对于腺病毒和肠病毒的存在均为阴性。由免疫球蛋白M的存在确定的急性PVB感染的血清学证据仅在一种情况下存在。在其余情况下，PVB被认为是与心肌炎无关联或关联有限的旁观者。结论：在这项研究中，腺病毒，肠病毒和PVB被发现是心肌炎的罕见病因。心肌尸检样品中PVB的检测极有可能代表一种持续性感染，与心肌炎症无关或有限。心肌炎症的法医调查需要彻底检查，包括特别注意非病毒原因，并且需要采取多学科方法。

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