Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study

Naganska Ewa; Matyja Ewa; Taraszewska Anna; Rafalowska Janina

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Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study

机译：谷氨酸兴奋毒性条件下丙戊酸对培养的运动神经元的保护作用。超微结构研究

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Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder that involves the upper and lower motor neurons and leads to the patient's death within 5 years after diagnosis. Approximately 2 per 100,000 people worldwide are affected every year The only FDA-approved drug available for medical treatment is riluzole. It slows the disease progression and improves limb function and muscle strength for 3-4 months. Thus, looking for new therapeutic agents is a pressing challenge.

机译：肌萎缩性侧索硬化症（ALS）是一种致命的神经退行性疾病，涉及上，下运动神经元，并在诊断后5年内导致患者死亡。每年全球约有每10万人中有2人受到影响。FDA批准的唯一可用于药物治疗的药物是利鲁唑。它可以减慢疾病的进程，并改善肢体功能和肌肉强度，持续3-4个月。因此，寻找新的治疗剂是紧迫的挑战。

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来源
《Folia neuropathologica》 |2015年第4期|共8页
作者
Naganska Ewa; Matyja Ewa; Taraszewska Anna; Rafalowska Janina;
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正文语种 eng
中图分类神经病学与精神病学;
关键词
amyotrophic lateral sclerosis; valproic acid; neuroprotection; ultrastructural study;

机译：肌萎缩性侧索硬化;丙戊酸;神经保护;超微结构研究;

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1. Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study [J] . Naganska Ewa, Matyja Ewa, Taraszewska Anna, Folia neuropathologica . 2015,第4期

机译：谷氨酸兴奋毒性条件下丙戊酸对培养的运动神经元的保护作用。超微结构研究
2. Protective effect of serofendic acid on glutamate-induced neurotoxicity in rat cultured motor neurons. [J] . Kume T, Kawai Y, Yoshida K, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2005,第3期

机译：血清硒酸对大鼠培养的运动神经元谷氨酸诱导的神经毒性的保护作用。
3. Neuroprotective Potential of Peptides HFRWPGP (ACTH_(6-9)PGP), KKRRPGP, and PyrRP in Cultured Cortical Neurons at Glutamate Excitotoxicity [J] . Bakaeva Z. V, Surin A. M., Lizunova N. V, Doklady biochemistry & biophysics . 2020,第MaraaApra期

机译：肽HFRwpGP（ACTH_（6-9）PGP），KKRRPGP和Pyrrp在谷氨酸兴奋毒性下培养的皮质神经元的神经保护潜力
4. Electrophysiological Detection of Cortical Neurons under Gamma-Aminobutyric Acid and Glutamate Modulation Based on Implantable Microelectrode Array Combined with Microinjection* [C] . Yilin Song, Guihua Xiao, Ziyue Li, . 2018

机译：植入式微电极阵列结合显微注射技术在γ-氨基丁酸和谷氨酸调节下对皮质神经元的电生理检测*
5. The contribution of the sodium-potassium-chlorine cotransporter to excitotoxicity in cultured neurons. [D] . Beck, Joseph Donald. 2003

机译：钠-钾-氯共转运蛋白对培养的神经元兴奋性毒性的贡献。
6. Effect of valproic acid on oxidative stress parameters of glutamate-induced excitotoxicity in SH-SY5Y cells [O] . Berna Terzioğlu Bebitoğlu, Elif Oğuz, Acet Gökçe 2020

机译：丙戊酸对谷氨酸诱导诱导毒性毒性氧化应激参数的影响SH-SY5Y细胞
7. Neuroprotection by chotosan, a Kampo formula, against glutamate excitotoxicity involves the inhibition of GluN2B-, but not GluN2A-containing NMDA receptor-mediated responses in primary cultured cortical neurons [O] . Sachie Sasaki-Hamada, Azusa Suzuki, Emi Sanai, 2017

机译：通过chotosan（一种汉方公式）对谷氨酸兴奋毒性的神经保护作用涉及GluN2B-的抑制，而不是原代培养皮层神经元中含GluN2a的NmDa受体介导的反应。

Protective effect of valproic acid on cultured motor neurons under glutamate excitotoxic conditions. Ultrastructural study

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