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首页> 外文期刊>Expert review of anticancer therapy >Differential diagnosis between primary lung squamous cell carcinoma and pulmonary metastasis of head and neck squamous cell carcinoma
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Differential diagnosis between primary lung squamous cell carcinoma and pulmonary metastasis of head and neck squamous cell carcinoma

机译：原发性肺鳞癌与头颈部鳞状细胞癌肺转移的鉴别诊断

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摘要

Differentiation between lung squamous cell carcinoma and pulmonary metastasis of head and neck squamous cell carcinoma is clinically important because the prognoses and therapeutic options are considerably different. However, the clinical, pathological, and immunohistochemical diagnostic methods have not yet been fully established. Although various molecular methods have been developed, they have not yet been practically applied. A combined approach involving molecular and immunohistochemical analysis, such as one that uses antibodies selected on the basis of comprehensive genetic analysis results, may be effective. We suggest a new diagnostic criteria using the clinical characteristics and the result of immunohistochemical analysis. However, there are two underlying problems in the development of new diagnostic methods: tumor heterogeneity and determination of the diagnostic accuracy.
机译：肺鳞状细胞癌与头颈部鳞状细胞癌的肺转移之间的区别在临床上很重要，因为其预后和治疗选择存在很大差异。但是，临床，病理和免疫组化诊断方法尚未完全建立。尽管已经开发了各种分子方法，但是它们尚未实际应用。涉及分子和免疫组织化学分析的组合方法（例如使用基于全面遗传分析结果选择的抗体的方法）可能是有效的。我们建议使用临床特征和免疫组化分析结果的新诊断标准。然而，在新的诊断方法的开发中存在两个潜在的问题：肿瘤异质性和诊断准确性的确定。

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