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首页> 外文期刊>Canadian Journal of Physiology and Pharmacology >Gap junctions and tumour progression.
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Gap junctions and tumour progression.

机译：间隙连接和肿瘤进展。

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摘要

Gap junctional intercellular communication has been implicated in growth control and differentiation. The mechanisms by which connexins, the gap junction proteins, act as tumor suppressors are unclear. In this review, several different mechanisms are considered. Since transformation results in a loss of the differentiated state, one mechanism by which gap junctions may control tumour progression is to promote or enhance differentiation. Processes of differentiation and growth control are mediated at the genetic level. Thus, an alternative or complimentary mechanism of tumour suppression could involve the regulation of gene expression by connexins and gap junctional coupling. Finally, gap junction channels form a conduit between cells for the exchange of ions, second messengers, and small metabolites. It is clear that the sharing of these molecules can be rather selective and may be involved in growth control processes. In this review, examples will be discussed that provide evidence for each of these mechanisms. Taken together, these findings point to a variety of mechanims by which connexins and the gap junction channels that they form may control tumour progression.
机译：间隙连接的细胞间通讯已经牵涉到生长控制和分化。连接蛋白，间隙连接蛋白，作为肿瘤抑制因子的机制尚不清楚。在这篇综述中，考虑了几种不同的机制。由于转化导致分化状态的丧失，因此间隙连接可控制肿瘤进展的一种机制是促进或增强分化。分化和生长控制过程在遗传水平上介导。因此，肿瘤抑制的替代或互补机制可能涉及通过连接蛋白和间隙连接偶联调节基因表达。最后，间隙连接通道在细胞之间形成导管，用于离子，第二信使和小代谢物的交换。显然，这些分子的共享可能具有相当的选择性，并可能参与生长控制过程。在这篇综述中，将讨论为每种机制提供证据的例子。综上所述，这些发现指出了多种机制，通过这些机制连接蛋白和它们形成的间隙连接通道可以控制肿瘤的进展。

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